The replacement of fossil resources that currently provide more than 90% of our energy needs and feedstocks of the chemical industry in combination with reduced emission of carbon dioxide is one of the most pressing challenges of mankind. Biomass as a globally available resource has been proposed as an alternative feedstock for production of basic building blocks, which could partially or even fully replace the currently utilized fossil-based ones in well-established chemical processes. The destruction of lignocellulosic feed followed by oxygen removal from its cellulose and hemicellulose content by catalytic processes results in the formation of initial platform chemicals (IPCs). However, their sustainable production strongly depends on the availability of resources, their efficient or even industrially viable conversion processes, and replenishment time of feedstocks. Herein, we overview recent advances and developments in catalytic transformations of the carbohydrate content of lignocellulosic biomass ...

Catalytic Conversion of Carbohydrates to Initial Platform Chemicals: Chemistry and Sustainability

Catalytic conversion of lignocellulosic biomass into chemicals and fuels

Biorefinery roadmap based on catalytic production and upgrading 5-hydroxymethylfurfural

https://pubs.rsc.org/en/content/articlepdf/2020/gc/c9gc04208c

An overview of the biphasic dehydration of sugars to 5-hydroxymethylfurfural and furfural: a rational selection of solvents using COSMO-RS and selection guides

5-hydroxymethylfurfural (HMF) is a very important versatile platform compound derived from renewable biomass. The functionalized molecule with an aldehyde group, a hydroxyl group and a furan ring provides great potential for the production of a wide variety of valuable chemicals. This review highlights the latest advances in the catalytic conversion of HMF into value-added chemicals by some important reactions including (1) aerobic oxidation of HMF into furan-based aldehydes and acids such as 5-hydroxymethyl-2-furancarboxylic acid (HMFCA), 2,5-diformylfuran (DFF), and furandicarboxylic acid (FDCA), (2) reductive amination of HMF to amine, (3) the synthesis of aromatics by Diels–alder reaction followed by a dehydration reaction, (4) catalytic reduction of HMF into 2,5-bis(hydroxymethyl)furan (BHMF), and 2,5-dimethyl furan (DMF), (5) catalytic oxidation of HMF into maleic anhydride, and some other important transformations. The review mainly focuses on the recent progress in bio-catalytic, electrocatalytic, and heterogeneous catalytic transformation of HMF into high value chemicals over the past few years. Moreover, an outlook is provided to highlight opportunities and challenges related to this hot research topic.

/pdf/efficient-conversion-of-5-hydroxymethylfurfural-to-high-3cq240ap0c.pdf

Efficient conversion of 5-hydroxymethylfurfural to high-value chemicals by chemo- and bio-catalysis

In this article, a series of novel quinoline derivatives of ursolic acid (UA) bearing hydrazide, oxadiazole, or thiadiazole moieties were designed, synthesised, and screened for their in vitro anti...

Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors

Catalytic conversion of carbohydrates to 5-hydroxymethylfurfural (5-HMF) provides a way toward obtaining renewable biomass-based fuels and chemicals. Herein, we use an inexpensive FePO4 catalyst, which is insoluble at low temperature but can be partially dissolved and act as a homogeneous catalyst at high temperature, in a one-vessel biphasic reactor to generate 5-HMF from carbohydrates such as fructose, glucose, sucrose, cellulose, and Camellia oleifera shell (a lignocellulosic feedstock) without the addition of homogeneous acids. The effects of various reaction conditions including reaction temperature, reaction time, feedstock types and the amount of catalyst on fructose conversion and 5-HMF yield were investigated. The highest 5-HMF yield (71.5 mol%) starting from fructose feedstock was achieved using this “one-pot” biphasic water/tetrahydrofuran (THF) reactor system at 140 °C for 15 min. More interestingly, at high temperature, the FePO4 catalyst was also highly active in the conversion of cellulose and Camellia oleifera shell, which are very difficult to convert to 5-HMF without the addition of mineral acids. A high 5-HMF yield of 48 mol% starting from microcrystalline cellulose was also obtained using the biphasic reaction system. Moreover, the FePO4 catalyst could be easily separated and recycled from the aqueous solution via precipitation after cooling to room temperature since it is insoluble at low temperature. Possible dehydration reaction mechanisms of these carbohydrates catalyzed by FePO4 were also proposed.

One-pot synthesis of 5-hydroxymethylfurfural from carbohydrates using an inexpensive FePO4 catalyst

A series of novel 2-aryl-benzimidazole derivatives of dehydroabietic acid were synthesized and characterized by IR, 1H NMR, 13C NMR, MS and elemental analyses. All the target compounds were evaluated for their in vitro cytotoxic activity against SMMC-7721, MDA-MB-231, HeLa and CT-26 cancer cell lines and the normal hepatocyte cell line QSG-7701 through MTT assays. Among them, compound 6j displayed the most potent cytotoxic activity with IC50 values of 0.08 ± 0.01, 0.19 ± 0.04, 0.23 ± 0.05 and 0.42 ± 0.07 μM, respectively, and substantially reduced cytotoxicity against QSG-7701 cells (5.82 ± 0.38 μM). The treatment of SMMC-7721 cells with compound 6j led to considerable inhibition of cell migration ability. The influence of compound 6j on cell cycle distribution was assessed on SMMC-7721 cells, exhibiting a cell cycle arrest at the G2/M phase. Moreover, tubulin polymerization assays and immunofluorescence assays elucidated that compound 6j could significantly inhibit tubulin polymerization and disrupt the intracellular microtubule network. A molecular docking study provided insight into the binding mode of compound 6j in the colchicine site of tubulin. In addition, compound 6j was found to induce apoptosis of SMMC-7721 cells, an increase of intracellular ROS level and a loss of mitochondrial membrane potential in a dose-dependent manner. These findings provided new molecular scaffolds for the further development of novel antitumor agents targeting tubulin polymerization.

/pdf/synthesis-and-biological-evaluation-of-2-aryl-benzimidazole-ashcscjmx3.pdf

Synthesis and biological evaluation of 2-aryl-benzimidazole derivatives of dehydroabietic acid as novel tubulin polymerization inhibitors

Aqueous zinc-based batteries are a very promising technology in the post-lithium era. However, excess zinc metals are often used, which results in not only making a waste but also lowering the actual energy density. Herein, a Ti3C2Tx/nanocellulose (derived from soybean stalks) hybrid film is prepared by a facile solution casting method and employed as the zinc-free anode for aqueous hybrid Zn-Li batteries. Benefiting from the ultra-low diameter and rich hydroxyl groups of nanocellulose, the hybrid film exhibits better mechanical properties, superior electrolyte wettability, and more importantly, significantly improved zinc plating/stripping reversibility compared to the pure Ti3C2Tx film. The hybrid film also dramatically overwhelms the stainless steel as the electrode for reversible zinc deposition. Further analysis shows that the hybrid film can lower the zinc deposition overpotential and promote the desolvation process of hydrated Zn2+ ions. In addition, it is found that hexagonal Zn thin flakes are horizontally deposited onto the hybrid film owing to the low lattice mismatch between the Ti3C2Tx surface and the (002) facet of Zn. Consequently, zinc dendritic growth and accompanied harmful side reactions can be considerably inhibited by the hybrid film, and the assembled Zn-Li hybrid batteries exhibit excellent electrochemical performances. This work might inspire future work on zinc-based batteries.

Flexible Ti3C2Tx/Nanocellulose Hybrid Film as a Stable Zn-free Anode for Aqueous Hybrid Zn-Li Batteries.

Ultrathin Zn-free anode based on Ti3C2Tx and nanocellulose enabling high-durability aqueous hybrid Zn-Na battery with Zn2+/Na+ co-intercalation mechanism

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