Hao Chang
Nanjing Medical University
11 Papers
2 Citations
Hao Chang is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 6, co-authored 10 publications.
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Papers
Protective Role of Fecal Microbiota Transplantation on Colitis and Colitis-Associated Colon Cancer in Mice Is Associated With Treg Cells
Zitao Wang,Wenjie Hua,Chen Li,Hao Chang,Ran Liu,Yangyue Ni,Hongzhi Sun,Yangyang Li,Xinyue Wang,Min Hou,Yu Liu,Zhipeng Xu,Minjun Ji +12 more
TL;DR: A previously unrecognized role for FMT is revealed in the treatment of CAC through restoring the intestinal microbiota and inducing regulatory T cells and an anti-inflammatory function of FMT was demonstrated by decreasing pro-inflammatory factors but increasing anti- inflammatory factors through inhibiting canonical NF-κB activity and cellular proliferation in colons of Cac mice.
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Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells.
Zhipeng Xu,Xiaoyun Zhang,Xiaoyun Zhang,Hao Chang,Yue Kong,Yangyue Ni,Ran Liu,Xiaolin Zhang,Yang Hu,Zhi Yang,Min Hou,Rui Mao,Wen-Tao Liu,Yasong Du,Shunying Yu,Zhen Wang,Minjun Ji,Zikai Zhou +17 more
TL;DR: In this paper, the authors used the soluble tachyzoite antigen from Toxoplasma gondii, a parasite that infects approximately two billion people, to induce MIA in mice.
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Fucoidan from seaweed Fucus vesiculosus inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis.
Tian Tian,Hao Chang,Kun He,Yangyue Ni,Chen Li,Min Hou,Lin Chen,Zhipeng Xu,Bin Chen,Minjun Ji +9 more
TL;DR: Results suggest that fucoidan, a natural seaweed-rich polysaccharide, has a potential therapeutic efficacy in the treatment of AD, and correlates with the induction of higher anti-inflammatory response through inducing Treg cells.
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Schistosoma japonicum infection causes a reprogramming of glycolipid metabolism in the liver
TL;DR: These findings reveal S. japonicum infection induces dynamic changes in the expression levels of genes involved in catabolism (glucose uptake, glycolysis and fatty acid oxidation) and suppressing anabolism in the liver, which could occur via macrophages’ metabolic states, particularly those involved in the AMPK, AKT and mTORC1 pathways.
Therapeutic potential of fucoidan in the reduction of hepatic pathology in murine schistosomiasis japonica
Xueqi Bai,Maining Li,Xinyue Wang,Hao Chang,Yangyue Ni,Chen Li,Kai-Yue He,Huiquan Wang,Yuxuan Yang,Tian Tian,Min Hou,Minjun Ji,Zhipeng Xu +12 more
TL;DR: An important role of natural fucoidan is suggested in reducing hepatic pathology in the progress of S. japonicum infection with a stronger Treg response, which may reveal a new potential therapeutic strategy for hepatic disease caused by parasitic chronic infection.