Hans P. Merkle
ETH Zurich
179 Papers
3K Citations
Hans P. Merkle is an academic researcher from ETH Zurich. The author has contributed to research in topics: PLGA & Chemistry. The author has an hindex of 73, co-authored 179 publications. Previous affiliations of Hans P. Merkle include École Polytechnique Fédérale de Lausanne & University of Bonn.
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Papers
Sustained release of heparin from polymeric particles for inhibition of human vascular smooth muscle cell proliferation
Zhihong Yang,Peter Birkenhauer,Friedgard Julmy,Donald E. Chickering,John P. Ranieri,Hans P. Merkle,Thomas F. Lüscher,Bruno Gander +7 more
TL;DR: Hparin encapsulated into PLGA microspheres was released over a prolonged period of time and thereby effectively reduced human SMC proliferation stimulated either with PDGF or serum, which may help to prevent restenosis after PTCA or to reduce graft disease after coronary bypass graft surgery.
Competitive adsorption of serum proteins at microparticles affects phagocytosis by dendritic cells.
TL;DR: Significant inhibition of phagocytosis was observed, even when HSA was combined with strong opsonins such as alpha2GP or IgG or in mixtures of all three proteins, indicating the importance of studying the influence of protein adsorption in protein mixtures.
Bilayer interaction and localization of cell penetrating peptides with model membranes: A comparative study of a human calcitonin (hCT)-derived peptide with pVEC and pAntp(43–58)
Michael E. Herbig,Ursina Fromm,Jeannine Leuenberger,Ulrike Krauss,Annette G. Beck-Sickinger,Hans P. Merkle +5 more
TL;DR: Strong peptide-phospholipid interactions are found, especially when negatively charged lipids were present, and localization profiles of CPPs obtained by Trp fluorescence quenching were dependent on the charge density of LUVs.
Cartilage-like tissue engineering using silk scaffolds and mesenchymal stem cells.
Sandra Hofmann,Sven Knecht,Robert Langer,David L. Kaplan,Gordana Vunjak-Novakovic,Gordana Vunjak-Novakovic,Hans P. Merkle,Lorenz Meinel,Lorenz Meinel,Lorenz Meinel +9 more
TL;DR: The results suggest that silk fibroin scaffolds are suitable biomaterial substrates for autologous cartilage tissue engineering in serum-free medium and enable mechanical improvements along with compositional features suitable for durable implants to generate or regenerate cartilage.
Silk based biomaterials to heal critical sized femur defects.
Lorenz Meinel,Lorenz Meinel,Lorenz Meinel,O. Betz,Roberto J. Fajardo,Sandra Hofmann,Sandra Hofmann,Ara Nazarian,E. Cory,Monika Hilbe,J. McCool,Robert Langer,Gordana Vunjak-Novakovic,Gordana Vunjak-Novakovic,Hans P. Merkle,Brigitte von Rechenberg,David L. Kaplan,Carl A. Kirker-Head +17 more
TL;DR: The pdHMSC/SS implants demonstrated osteogenic ability in vitro and capacity to thrive towards the healing of critical size femoral segmental defects in vivo and provide an alternative protein-based biomaterial for load bearing applications.