Hans Hauner
Technische Universität München
569 Papers
3.2K Citations
Hans Hauner is an academic researcher from Technische Universität München. The author has contributed to research in topics: Medicine & Adipose tissue. The author has an hindex of 76, co-authored 497 publications. Previous affiliations of Hans Hauner include University of Düsseldorf & University of Ulm.
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Papers
Relationship between adipocyte size and adipokine expression and secretion.
TL;DR: There seems to be a differential expression of pro- and antiinflammatory factors with increasing adipocyte size resulting in a shift toward dominance of proinflammatory adipokines largely as a result of a dysregulation of hypertrophic, very large cells.
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Melina Claussnitzer,Simon N. Dankel,Kyoung-Han Kim,Gerald Quon,Wouter Meuleman,Christine Haugen,Viktoria Glunk,Isabel S. Sousa,Jacqueline L. Beaudry,Vijitha Puviindran,Nezar Abdennur,Jannel Liu,Per-Arne Svensson,Yi-Hsiang Hsu,Daniel J. Drucker,Gunnar Mellgren,Chi-chung Hui,Hans Hauner,Manolis Kellis,Manolis Kellis +19 more
TL;DR: The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.
T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance.
Ulrich Kintscher,Martin Hartge,Katharina Hess,Anna Foryst-Ludwig,Markus Clemenz,Martin Wabitsch,Pamela Fischer-Posovszky,Thomas F. E. Barth,Duska Dragun,Thomas Skurk,Hans Hauner,Matthias Blüher,Thomas Unger,Anna-Maria Wolf,Uwe Knippschild,Vinzenz Hombach,Nikolaus Marx +16 more
TL;DR: Proinflammatory T-lymphocytes are present in visceral adipose tissue and may contribute to local inflammatory cell activation before the appearance of macrophages, suggesting that these cells could play an important role in the initiation and perpetuation of adipOSE tissue inflammation as well as the development of IR.
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Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation
Martin Wabitsch,Brenner Re,Ingo Melzner,Michael Braun,Peter Möller,Eberhard Heinze,Klaus-Michael Debatin,Hans Hauner +7 more
TL;DR: The human cell strain described here provides an almost unlimited source of human preadipocytes with high capacity for adipose differentiation and may, therefore, represent a unique tool for studying human fat cell development and metabolism.
571
Insulin and Cortisol Promote Leptin Production in Cultured Human Fat Cells
Martin Wabitsch,Per Bo Jensen,Werner F. Blum,Claus T Christoffersen,P Englaro,Eberhard Heinze,Wolfgang Rascher,Walter M. Teller,Hans Tornqvist,Hans Hauner +9 more
TL;DR: Results clearly indicate that both insulin and cortisol are potent and possibly physiological regulators of leptin expression in human adipose tissue.
513