Hans H. Hirsch
University Hospital of Basel
415 Papers
2.4K Citations
Hans H. Hirsch is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Medicine & Transplantation. The author has an hindex of 69, co-authored 387 publications. Previous affiliations of Hans H. Hirsch include Triemli Hospital & University of Stuttgart.
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Papers
Use of Viral Load as a Surrogate Marker in Clinical Studies of Cytomegalovirus in Solid Organ Transplantation: A Systematic Review and Meta-analysis.
Yoichiro Natori,Ali Alghamdi,Mahmood Tazari,Veronica Miller,Shahid Husain,Takashi E. Komatsu,Paul D. Griffiths,Per Ljungman,Ani Orchanian-Cheff,Deepali Kumar,Atul Humar,Rekha Abichandani,Barbara D. Alexander,Robin K. Avery,Fausto Baldanti,Susan Barnett,Paul Baum,M Michelle Berrey,Debra Birnkrant,Emily A. Blumberg,Michael Boeckh,David Boutolleau,Terry Bowlin,Jennifer Brooks,Roy F. Chemaly,Sunwen Chou,Gavin Cloherty,William Cruikshank,Lesia K. Dropulic,Hermann Einsele,Jay Erdman,Gary Fahle,Lynn Fallon,Heather Gillis,Dimitri Gonzalez,Kurt Gunter,Hans H. Hirsch,Aimee Hodowanec,Peter W. Hunt,Filip Josephson,Camille N. Kotton,Philip R. Krause,Frank Kuhr,Christopher Lademacher,Randall Lanier,Tadd Lazarus,John A. D. Leake,Randi Y. Leavitt,Sandra Nusinoff Lehrman,Li Li,Paula Isabelle Lodding,Jens D Lundgren,Francisco Martinez-Murillo,Howard Mayer,Megan McCutcheon,John E. McKinnon,Thomas Mertens,Kevin Modarress,Johann Mols,Sally Mossman,Yoshihiko Murata,David Murawski,Jeffrey C. Murray,Garrett Nichols,Jules O'Rear,Karl S. Peggs,Andreas Pikis,Mark N. Prichard,Raymund R. Razonable,Marcie L. Riches,Jeff Roberts,Wael Saber,Chalom Sayada,Mary Singer,Thomas Stamminger,Anna Wijatyk,Dong Yu,Bernhardt Zeiher +77 more
TL;DR: It is concluded that CMV load is an appropriate surrogate endpoint for CMV trials in organ transplant recipients due to low frequency of disease and several lines of evidence support the validity of viral load.
Management and outcome of CSF-JC virus PCR-negative PML in a natalizumab-treated patient with MS
Jens Kuhle,Rainer Gosert,R. Buhler,Tobias Derfuss,Raoul Sutter,Özgür Yaldizli,E. W. Radue,Caroline F. Ryschkewitsch,Eugene O. Major,Ludwig Kappos,Stephan Frank,Hans H. Hirsch +11 more
TL;DR: This case illustrates diagnostic challenges in the context of incomplete suppression of immune surveillance and the potential of recovery of PML associated with efficient immune function restitution in a 49-year-old woman with multiple sclerosis.
JC Virus-Specific Immune Responses in Human Immunodeficiency Virus Type 1 Patients with Progressive Multifocal Leukoencephalopathy
Nina Khanna,Nina Khanna,Marcel Wolbers,Nicolas J. Mueller,Christian Garzoni,Renaud Du Pasquier,Christoph A Fux,Pietro Vernazza,Enos Bernasconi,Raphael P. Viscidi,Manuel Battegay,Hans H. Hirsch,Hans H. Hirsch +12 more
TL;DR: It is concluded that PML nonsurvivors had selectively impaired JCV-specific T-cell responses compared to CD4+ T- cell-matched controls and failed to mount J CV-specific antibody responses.
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Cellular immune responses to BK virus.
TL;DR: Advances in immunological techniques will provide further insight into the specificity and patterns of cellular response to BKV, which should assist translation into improved patient management and development of immunotherapeutic approaches.
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Reevaluating and Optimizing Polyomavirus BK and JC Real-Time PCR Assays To Detect Rare Sequence Polymorphisms
TL;DR: The aim of this study was to review the in-house polyomavirus BK (BKV) and JC (JCV) real-time PCR assays and conclude that the JCV and updated BKV real- time PCR Assays are robust and detect rare variants possibly encountered in the clinical routine.