Hangyan Dong
Protein Sciences
6 Papers
7 Citations
Hangyan Dong is an academic researcher from Protein Sciences. The author has contributed to research in topics: Chemistry & Proteome. The author has an hindex of 4, co-authored 6 publications.
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Papers
Development a hydrazide-functionalized thermosensitive polymer based homogeneous system for highly efficient N-glycoprotein/glycopeptide enrichment from human plasma exosome.
Haihong Bai,Yiting Pan,Lu Qi,Long Liu,Xinyuan Zhao,Hangyan Dong,Xiaoqiang Cheng,Weijie Qin,Xinghe Wang +8 more
TL;DR: A hydrazide functionalized thermosensitive polymer is developed for efficient enrichment and in-depth identification of protein N-glycosylation in human plasma exosome by mass spectrometry and found 26 N- Glycoproteins significantly changed between the glioma patients and the healthy subjects, demonstrating the potential of this new strategy for N- glycoproteome research of plasma exOSome and biomarker discovery.
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An Integrated Strategy for Mass Spectrometry-Based Multiomics Analysis of Single Cells.
Yuanyuan Li,Hang Li,Yuping Xie,Shuo Chen,Ritian Qin,Hangyan Dong,Yong-Liang Yu,Jian-Hua Wang,Xiaohong Qian,Weijie Qin,Weijie Qin +10 more
TL;DR: In this paper, a microwell chip was prepared and the internal surface was modified for hydrophilic interaction liquid chromatography-based tandem extraction of metabolites and proteins and subsequent protein digestion.
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Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry
Wanjun Zhang,Tong Liu,Hangyan Dong,Haihong Bai,Fang Tian,Zhaomei Shi,Ming-Li Chen,Jian-Hua Wang,Weijie Qin,Xiaohong Qian +9 more
TL;DR: A novel thermosensitive immobilized triarylphosphine reagent enables efficient enrichment and sensitive detection of more than 1700 potential O-GlcNAc proteins from HeLa cell using mass spectrometry, demonstrating its potential as a general strategy for low-abundance target enrichment.
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A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.
Bianbian Huo,Bianbian Huo,Wanjun Zhang,Xinyuan Zhao,Hangyan Dong,Yong-Liang Yu,Jian-Hua Wang,Xiaohong Qian,Weijie Qin +8 more
TL;DR: Facile sample recovery, enhanced ionization and fragmentation in MS of the enriched PTM peptides are achieved, which leads to the identification of 3293 O-GlcNAc peptides and the location of 1706 sites in HeLa cells and efficiently expands the current mapping scale.
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An RNA tagging approach for system-wide RNA-binding proteome profiling and dynamics investigation upon transcription inhibition
TL;DR: In this article, a psoralen probe (PP)-based method for RNA tagging and ribonucleic-protein complex (RNP) enrichment was developed for RNA-protein interactions.