Hang Wang
Nankai University
17 Papers
Hang Wang is an academic researcher from Nankai University. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 5, co-authored 7 publications.
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Papers
Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer
Huimin Jiang,H. Wei,Hang Wang,Zhaoyang Wang,Jianjun Li,Yang-Ming Ou,Xiao Xiao,Wenhao Wang,Antao Chang,Wei Sun,Li Zhao,Shuang Yang +11 more
TL;DR: In this article , ectopic Zeb1 directly increases the transcriptional expression of HK2, PFKP, and PKM2, thus promoting the Warburg effect and breast cancer proliferation, migration, and chemoresistance in vitro and in vivo.
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Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1.
Huimin Jiang,Chen Zhou,Zhen Zhang,Qiong Wang,Huimin Wei,Wen Shi,Jianjun Li,Zhaoyang Wang,Yang Ou,Wenhao Wang,Hang Wang,Quansheng Zhang,Wei Sun,Peiqing Sun,Shuang Yang +14 more
TL;DR: It is highlighted that targeting the angiocrine Jag1-Notch1-Zeb1-VEGFA loop decreases breast cancer aggressiveness and thus enhances the efficacy of antiangiogenic therapy.
CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism.
Zhen Zhang,Jianjun Li,Yang Ou,Guang Yang,Kaiyuan Deng,Qiong Wang,Zhaoyang Wang,Wenhao Wang,Quansheng Zhang,Hang Wang,Wei Sun,Peiqing Sun,Shuang Yang +12 more
TL;DR: Evidence is provided that the CDK4/6-USP51-ZEB1 axis plays a key role in breast cancer metastasis and could be a viable therapeutic target for the treatment of advanced human cancers.
Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
Shaorong Zhao,Jianjun Li,Guomin Zhang,Qiong Wang,Chao Wu,Quansheng Zhang,Hang Wang,Peiqing Sun,Rong Xiang,Shuang Yang +9 more
TL;DR: This study provides the novel finding that exosomal miR-451a targets LPIN1 to inhibit hepatocellular tumorigenesis by regulating tumor cell apoptosis and angiogenesis, and has clinical implications regarding the deregulation of miRNAs in HCC.
USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer
Jianjun Li,Xiao Xiao,Yang-Ming Ou,Lixia Cao,Min Guo,C. Qi,Zhaoyang Wang,Yuxin Liu,Q. Shuai,Hang Wang,Peiqing Sun,Yi Shi,Guang Yang,Shuang Yang +13 more
TL;DR: In this article , the authors investigated the role of PD-L1 signaling in mediating chemotherapeutic resistance in non-small cell lung cancer (NSCLC) and found that ubiquitin-specific peptidase 51 (USP51)/PD•L1/integrin beta•1 (ITGB1) signaling performed a cell-intrinsic role in mediATING chemotherAPEutic resistance.
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