Handfield Robert Eugene
Pfizer
6 Papers
39 Citations
Handfield Robert Eugene is an academic researcher from Pfizer. The author has contributed to research in topics: Aryl & Side chain. The author has an hindex of 4, co-authored 6 publications.
Chat about Author
Papers
Development of a Practical and Convergent Process for the Preparation of Sulopenem
Steven J. Brenek,Stephane Caron,Esmort Chisowa,Mark P. Delude,Michele T. Drexler,Marcus Ewing,Handfield Robert Eugene,Nathan D. Ide,Durgesh V. Nadkarni,Jade D. Nelson,Mark Olivier,Hahdi H. Perfect,James E. Phillips,John J. Teixeira,R. Matt Weekly,John P. Zelina +15 more
TL;DR: In this paper, a convergent process for the large-scale preparation of sulopenem was proposed, where cyclization of an oxalimide intermediate was used to provide the thiopenem core.
18
Development of a Second-Generation Process to Antibacterial Candidate Sulopenem
Steven J. Brenek,Stephane Caron,Esmort Chisowa,Roberto Colon-Cruz,Mark P. Delude,Michele T. Drexler,Handfield Robert Eugene,Brian P. Jones,Durgesh V. Nadkarni,Jade D. Nelson,Mark Olivier,R. Matt Weekly,G. C. A. Bellinger,Zinka Brkic,Neil Choi,Joe Desneves,Marcia A.-P. Lee,Wayne Pearce,Jessica K. Watson +18 more
TL;DR: In this article, the authors present the research, development, and scale-up of the broad spectrum antibacterial candidate sulopenem, where the penem ring is constructed via a modified Eschenmoser sulfide contraction sequence.
9
Patent
Process for the preparation of 1,3-substituted indenes
Handfield Robert Eugene,Timothy J. N. Watson,Phillip J. Johnson,Peter Robert Rose +3 more
- 17 Nov 2003
TL;DR: An improved process for the preparation of substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders is described in this paper.
7
Patent
Process for the preparation of aryl fused polycyclic lactams
Handfield Robert Eugene,Timothy J. N. Watson +1 more
- 08 Jan 2004
TL;DR: In this article, a process for the preparation of aryl fused polycyclic lactams of formulaI which are useful intermediates in the synthesis of ayrl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders is described.
4
Synthesis of (1‐(Aminomethyl)‐2,3‐dihydro‐1H‐inden‐3‐yl)methanol: Structural Confirmation of the Main Band Impurity Found in Varenicline® Starting Material
Busch Frank R,Paul E. Concannon,Handfield Robert Eugene,Jason D. McKinley,Megan McMahon,Robert A. Singer,Timothy J. N. Watson,Gregory J. Withbroe,Mariano Stivanello,Lucia Leoni,Chiara Bezze +10 more
TL;DR: In this paper, the main band impurity of 1 was found in the synthesis of 2, and the structure of 1, the open-ring product of the lithium aluminum hydride (LAH) reduction of 3 to 2.
3