Handan Can
University of Nebraska–Lincoln
13 Papers
136 Citations
Handan Can is an academic researcher from University of Nebraska–Lincoln. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Handan Can include Yeditepe University & Istanbul Bilgi University.
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Papers
Metagenomic analysis of the microbial community in kefir grains
Ufuk Nalbantoglu,Atilla Cakar,Haluk Dogan,Neslihan Abaci,Duran Ustek,Khalid Sayood,Handan Can +6 more
TL;DR: The results suggest that microbial community profiling using whole genome shotgun data is feasible, can identify novel species data, and has the potential to generate a more accurate and detailed assessment of the underlying bacterial community, especially for low abundance species.
151
Prediction of Diabetic Nephropathy Using Urine Proteomic Profiling 10 Years Prior to Development of Nephropathy
Hasan H. Otu,Handan Can,Handan Can,Dimitrios Spentzos,Robert G. Nelson,Robert L. Hanson,Helen C. Looker,William C. Knowler,Manuel Monroy,Towia A. Libermann,S. Ananth Karumanchi,Ravi Thadhani +11 more
TL;DR: In this article, the authors examined whether proteomic technologies identify novel urine proteins associated with subsequent development of diabetic nephropathy in subjects with type 2 diabetes before evidence of microalbuminuria.
115
Restoration of Liver Mass after Injury Requires Proliferative and Not Embryonic Transcriptional Patterns
Hasan H. Otu,Hasan H. Otu,Kamila Naxerova,Karen J. Ho,Handan Can,Handan Can,Nicole Nesbitt,Towia A. Libermann,Seth J. Karp +8 more
TL;DR: It is suggested that at a transcriptional level restoration of liver mass after injury is best described as hepatocyte hyperplasia and not true regeneration, and this novel pattern of gene expression may underlie the unique capacity of the liver to repair itself after injury.
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Whole Genome Sequence of a Turkish Individual
TL;DR: The results suggest that whole genome sequencing is a valuable tool for understanding variations in the human genome across different populations, and that detailed analyses of genomes of diverse origins greatly benefits research in genetics and medicine and should be conducted on a larger scale.
Genomic expression pathways associated with brain injury after cardiopulmonary bypass
Basel Ramlawi,Hasan H. Otu,James L. Rudolph,Shigetoshi Mieno,Isaac S. Kohane,Handan Can,Towia A. Libermann,Edward R. Marcantonio,Cesario Bianchi,Frank W. Sellke +9 more
TL;DR: Patients with neuroc cognitive decline have inherently different genetic responses to cardiopulmonary bypass compared with those of patients without neurocognitive decline, and genetic variations in inflammatory, cell adhesion, and apoptotic pathways might be important contributors to the pathophysiology of neurologic injury after cardiac surgery.
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