Han Yao
Ghent University
10 Papers
16 Citations
Han Yao is an academic researcher from Ghent University. The author has contributed to research in topics: Ion trap & Mass spectrometry. The author has an hindex of 5, co-authored 9 publications.
Chat about Author
Papers
Circular dichroism in functional quality evaluation of medicines.
TL;DR: The basic principles of the CD technique are initially described, followed by a systematic literature research on pharmaceutical aspects encompassing chiral small molecules, bio‐polymers, medicine‐target interaction and medicine changes.
54
An analytical quality by design (aQbD) approach for a l-asparaginase activity method
Han Yao,Jochem Vancoillie,Matthias D'Hondt,Evelien Wynendaele,Nathalie Bracke,Bart De Spiegeleer +5 more
TL;DR: This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles.
26
Peptide profiling of Internet‐obtained Cerebrolysin using high performance liquid chromatography – electrospray ionization ion trap and ultra high performance liquid chromatography – ion mobility – quadrupole time of flight mass spectrometry
Bert Gevaert,Matthias D'Hondt,Nathalie Bracke,Han Yao,Evelien Wynendaele,Johannes Petrus Cornelis Vissers,Martin De Cecco,Jan Claereboudt,Bart De Spiegeleer +8 more
TL;DR: Cerebrolysin, a parenteral peptide preparation produced by controlled digestion of porcine brain proteins, is an approved nootropic medicine in some countries, but until now, its exact chemical composition was unknown.
18
A Surface Acoustic Wave (SAW) biosensor method for functional quantification of E. coli l-asparaginase
TL;DR: This work presents a SAW biosensor based approach for the functional quantification of Escherichia colil-asparaginase, using polyclonal antibody (pAb) as the interaction partner immobilized on the chip, and suggests this SAW method can be adopted as a pharmaceutical QC method.
15
Development of a capillary zone electrophoresis method to quantify E. coli L-asparaginase and its acidic variants
Han Yao,Jana Vandenbossche,Cari Sänger van de Griend,Yorick Janssens,Cristina Soto Fernández,Xiaolong Xu,Evelien Wynendaele,Govert W. Somsen,Rob Haselberg,Bart De Spiegeleer +9 more
TL;DR: A capillary zone electrophoresis method with UV detection was developed for the quantification of the E.colil-asparaginase (l-ASNase) and its acidic variants and was validated for linearity, accuracy, precision, LOD, LOQ and robustness.
10