Comprehensive energy analysis and environmental sustainability of industrial grain drying

Inactivated and live attenuated vaccines are the mainstays of preventing viral poultry diseases. However, the development of recombinant DNA technology in recent years has enabled the generation of recombinant virus vector vaccines, which have the advantages of preventing multiple diseases simultaneously and simplifying the vaccination schedule. More importantly, some can induce a protective immune response in the presence of maternal antibodies and offer long-term immune protection. These advantages compensate for the shortcomings of traditional vaccines. This review describes the construction and characterization of primarily poultry vaccine vectors, including fowl poxvirus (FPV), fowl adenovirus (FAdV), Newcastle disease virus (NDV), Marek’s disease virus (MDV), and herpesvirus of turkey (HVT). In addition, the pathogens targeted and the immunoprotective effect of different poultry recombinant virus vector vaccines are also presented. Finally, this review discusses the challenges in developing vector vaccines and proposes strategies for improving immune efficacy. 

Current Status of Poultry Recombinant Virus Vector Vaccine Development

Infectious bursal disease (IBD) is one of the dangerous diseases of poultry that affects the bursa of Fabricius, which is an important organ of the bird’s immune system. IBD virus is resistant to many drugs, making its control difficult. Vaccination of IBD is in practice for a long time worldwide to control IBD, but secondary issues like vaccine failure and lower efficacy lead to their reduced use in the field. Multiple medicines are currently used, but the phytochemicals have emerged as promising agents for controlling IBD. The drugs to be developed should possess direct antiviral properties by targeting viral entry mechanisms, enhancing the host immune response, and inhibiting viral protein synthesis. Phytochemicals have potential to contribute to food security by minimizing the possibility of disease outbreaks and ensuring that consumers worldwide obtain healthy poultry products. It has been now claimed that direct and indirect activities of phytochemicals can be effective in the control of IBDV. Although available evidence suggest that the phytochemicals can contribute in controlling occurrence IBDV, there is a definite need of focused studies to gain more insight and develop rational strategies for their practical use. This review highlights the disease caused by IBDV, inhibition of viral replication, boosting the immune system, disruption of viral membrane, and important phytochemicals showing antiviral activities against IBDV. 

pdf/phytochemicals-a-promising-approach-to-control-infectious-5b8shvjqt8.pdf

Phytochemicals: a promising approach to control infectious bursal disease

Newcastle disease (ND) and infectious bursal disease (IBD) are two key infectious diseases that significantly threaten the health of the poultry industry. Although existing vaccinations can effectively prevent and treat these two diseases through multiple immunizations, frequent immunization stresses significantly impact chicken growth. In this study, three recombinant adenoviruses, rAd5-F expressing the NDV (genotype VII) F protein, rAd5-VP2 expressing the IBDV VP2 protein, and rAd5-VP2-F2A-F co-expressing F and VP2 proteins, were constructed using the AdEasy system. The F and VP2 genes of the recombinant adenoviruses could be transcribed and expressed normally in HEK293A cells as verified by RT-PCR and Western blot. The three recombinant viruses were shown to have similar growth kinetics as rAd5-EGFP. Compared with the PBS and rAd5-EGFP groups, SPF chickens immunized with recombinant adenoviruses produced higher antibody levels, more significant lymphocyte proliferation, and significantly higher CD4+/CD3+ and CD8+/CD3+ cells in peripheral blood. The survival rate of SPF chickens immunized with rAd5-F and rAd5-VP2-F2A-F after the challenge with DHN3 was 100%, and 86% of SPF chickens showed no viral shedding at 7 dpc. The survival rate of SPF chickens immunized with rAd5-VP2 and rAd5-VP2-F2A-F after the challenge with BC6/85 was 86%. rAd5-VP2 and rAd5-VP2-F2A-F significantly inhibited bursal atrophy and pathological changes compared to the rAd5-EGFP and PBS groups. This study provides evidence that these recombinant adenoviruses have the potential to be developed into safe and effective vaccine candidates for the prevention and control of ND and IBD.

https://www.mdpi.com/2076-393X/11/6/1051/pdf?version=1685667895

Construction and Evaluation of the Immunogenicity and Protective Efficacy of Recombinant Replication-Deficient Human Adenovirus-5 Expressing Genotype VII Newcastle Disease Virus F Protein and Infectious Bursal Disease Virus VP2 Protein

The heat exchanger is the key component of an industrial drying system. The present work introduced a novel tube heat exchanger into a corn drying system. To fully understand the heat exchange process and optimize the heat exchange performance of the heat exchanger, numerical simulation, exergy analysis and economic analysis methodologies were adopted to analyze the comprehensive performance of the heat exchanger. The fluid dynamics as well as the exergy performance of the heat exchanger under different flue gas velocities (3, 5 and 7m/s) and different ambient air relative humidities (80%, 85% and 90%) were investigated. The results showed that there are two strong turbulences causing the huge pressure drop at the last two stages of the flue gas duct, while there are two insufficient heat exchange areas on both sides of the heat exchanger; thus, the corresponding improvement recommendations were proposed in the present work. The values of the Re and Nu were found to vary in the range of 1256.275–2210.554 and 21.337–32.415, respectively. The average heat transfer coefficients were ascertained to be above 8.274 kW·m−2·K−1, while the pressure drop of the ambient air was ascertained to be under 16.138 Pa. Moreover, the exergy analysis revealed that the heat exchanger experiences sustainable development (SI < 2), and the exergy efficiency is above 11.461%. The main results may provide some references for further optimizing the heat transfer performance of the heat exchanger.

/pdf/experimental-and-numerical-study-on-the-fluid-dynamics-and-7py9z60k.pdf

Experimental and Numerical Study on the Fluid Dynamics and Exergetic Performance of the Heat Exchanger in an Industrial Corn Drying System

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Construction and Evaluation of the Immunogenicity and Protective Efficacy of Recombinant Replication-Deficient Human Adenovirus-5 Expressing Genotype VII Newcastle Disease Virus F Protein and Infectious Bursal Disease Virus VP2 Protein

Experimental and Numerical Study on the Fluid Dynamics and Exergetic Performance of the Heat Exchanger in an Industrial Corn Drying System