5 Papers
71 Citations
Han Si is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Han Si include University of Pennsylvania & Yeshiva University.
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Papers
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
Bernhard Bielesz,Yasemin Sirin,Yasemin Sirin,Han Si,Thiruvur Niranjan,Antje Gruenwald,Seon-Ho Ahn,Hideki Kato,James Pullman,Manfred Gessler,Volker H. Haase,Katalin Susztak +11 more
TL;DR: It is established that epithelial injury and Notch signaling play key roles in fibrosis development and indicate that Notch blockade may be a therapeutic strategy to reduce fibrosis and ESRD development.
Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development
Yi-An Ko,Davoud Mohtat,Masako Suzuki,Ae Seo Deok Park,María Concepción Izquierdo,Sang Youb Han,Hyun Mi Kang,Han Si,Thomas H. Hostetter,James Pullman,Melissa Fazzari,Amit Verma,Deyou Zheng,John M. Greally,Katalin Susztak +14 more
TL;DR: It is demonstrated that genome-wide cytosine methylation patterns of healthy and chronic kidney disease tubule samples obtained from patients show significant differences, raising the possibility that epigenetic dysregulation plays a role in chronic kidneys disease development via influencing core pro-fibrotic pathways and can aid the development of novel biomarkers and future therapeutics.
Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function
Mariana Murea,Jun Ki Park,Shuchita Sharma,Hideki Kato,Antje Gruenwald,Thiruvur Niranjan,Han Si,David B. Thomas,James Pullman,Michal L. Melamed,Katalin Susztak +10 more
TL;DR: The results raise the possibility that Notch pathway activation is a common mechanism in the pathophysiology of a wide range of acquired renal diseases.
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Human and murine kidneys show gender- and species-specific gene expression differences in response to injury.
Han Si,Ramandeep S. Banga,Pinelopi P. Kapitsinou,Manjunath Ramaiah,Janis Lawrence,Ganesh Kambhampati,Antje Gruenwald,Erwin P. Bottinger,Daniel Glicklich,V Tellis,Stuart M. Greenstein,David B. Thomas,James Pullman,Melissa Fazzari,Katalin Susztak +14 more
TL;DR: It is shown that sexually dimorphic genes in the kidney show species specific regulation and male and female kidneys respond differently to injury.
Smad1 as a Biomarker for Diabetic Nephropathy
TL;DR: To identify patients at increased risk for the development of diabetic nephropathy, considerable scientific effort has been dedicated to developing new screening and prognostic markers, and the hope is that these new biomarkers will predict theDevelopment of the disease earlier than the currently used disease marker, albuminuria.
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