Han Moshage
University Medical Center Groningen
181 Papers
1.8K Citations
Han Moshage is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Hepatic stellate cell & Apoptosis. The author has an hindex of 50, co-authored 161 publications. Previous affiliations of Han Moshage include University of Texas Health Science Center at Houston & University of Groningen.
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Papers
Nitric oxide inhibition enhances platelet aggregation in experimental anti-Thy-1 nephritis.
Harry van Goor,Ester W.J.A. Albrecht,Peter Heeringa,Pieter A. Klok,Marian L.C. van der Horst,Alie de Jager-Krikken,Winston W. Bakker,Han Moshage +7 more
TL;DR: It is concluded that the inflammatory infiltrate in Thy-1 nephritis develops independent of NO radical production, whereas NO radicals prevent the accumulation of platelet aggregates.
19
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes.
TL;DR: Hsperetin protected against palmitate-induced hepatic cell death via activation of the sXBP1/GRP78 signaling pathway, thus inhibiting palmitATE-induced ER stress, and high concentrations of hesperetIn induce ER stress and subsequently cause cell death in hepatocytes.
18
Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation after eIF2α/ATF4 Pathway Activation.
W Alfredo Ríos-Ocampo,María Cristina Navas,Manon Buist-Homan,Klaas Nico Faber,Toos Daemen,Han Moshage +5 more
TL;DR: It is demonstrated that hepatocyte-like cells expressing HCV proteins and additionally exposed to oxidative stress adapt to cellular stress through eIF2a/ATF4 activation and selective degradation of HCV pro-oxidant proteins Core and NS5A and results in increased resistance to apoptotic cell death induced by oxidative stress.
17
Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes
Marieke H. Schoemaker,Jenny E. Kootstra-Ros,Manon Buist-Homan,Christian Trautwein,P Liston,Klaas Poelstra,van Harry Goor,Plm Jansen,Han Moshage +8 more
- 01 Jan 2002
TL;DR: In this article, the relationship between NF-kappaB activation and apoptosis has been investigated in hepatocytes and the expression and regulation of apoptosis-related genes were investigated.
16
Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity
Esther M. Verhaag,Manon Buist-Homan,Martijn Koehorst,Albert K. Groen,Han Moshage,Klaas Nico Faber +5 more
TL;DR: Sub-toxic concentrations of bile acids in the range that occur under normal physiological conditions protect HepG2.rNtcp cells against GCDCA-induced apoptosis, which is independent of FXR-controlled changes in bile acid transport.