The invention provides a tracheal stent, a tissue engineering trachea adopting the tracheal stent and application of the tracheal stent and tissue engineering trachea. The tracheal stent comprises a plurality of supporting rings which are arranged at intervals, wherein a hollow reticular supporting part is arranged between adjacent supporting rings. The tracheal stent has the advantages of excellent supporting capacity, relatively good cartilage which is identified by a dyeing means can be formed within two weeks and can be directly used for transplanting, while the stent reported in the prior art can be transplanted for at least two months generally; and the tracheal stent in the prior art is cultured in vitro firstly, subcutaneously pre-transplanted on animals and then is taken out for transplanting, but the cartilage formed by virtue of the tracheal stent within two weeks can be transplanted without animal subcutaneous pre-transplanting.

Tracheal stent, tissue engineering trachea adopting tracheal stent and application of tracheal stent and tissue engineering trachea

The invention discloses a personalized airway stent manufacturing technology.A personalized airway stent is manufactured by utilizing a CT image to reestablish an airway stenosis model of a patient, expanding the stenosis of the airway model in three-dimensional numerical model reestablishment software by 20%-40% and then outwards expanding the wall face of the outmost side of the processed airway model by 10% to form the outer wall of the stent.A three-dimensional numerical model of the personalized airway stent is designed through the processing.Finally, the personalized airway stent model is imported into a 3D printer, and silicone and other medical biological materials are injected to manufacture the personalized stent conforming to the airway structure of the patient.Three-dimensional modeling is performed according to airway stenosis of different patients, the personalized airway stents are designed, and the shortcomings and defects that existing commercial airway stents difficultly fit the airways of the patients and granulation tissue proliferation is easily caused are overcome.

Personalized airway stent manufacturing technology

The invention discloses a degradable and extratracheal suspending support and an indirect 3D printing method thereof. The support is provided with several C-shaped cylindrical ring structures, the C-shaped cylindrical ring structures are arranged in an array mode, the opening angle of the cylindrical rings is 90 degrees, and the surface of each C-shaped cylindrical ring structure is in an arc shape, so that the extratracheal support shows fluctuating heave-and-sunken structures as a whole; on the C-shaped cylindrical ring structures, penetrating holes are punched at every 90 degrees on the protrusion structures. The indirect 3D printing method of the support comprises the steps of using a 3D printing technology to manufacture resin parts formed by internal dies and external dies, cleaning clearly the resin parts, using biological silica gel to conduct rollover on the resin parts, preheating the obtained silica gel die, afterwards adding a medical biological degradable material in a silica gel external die, conducting vacuum pumping treatment after the material is totally fused, afterwards putting the fused material into a silica internal die to fix the material, naturally cooling, demolding the material after the material cools down to obtain the degradable and extratracheal suspending support. The manufactured degradable and extratracheal suspending support has high mechanical performance and surface roughness, and has an in-vivo degradable property.

Degradable and extratracheal outer suspending support and indirect 3D printing method thereof

The invention relates to a covered airway stent. The covered airway stent is characterized by comprising a framework of a tubular structure or a superior-arc-shaped structure and a membrane structure covering the outer wall of the framework, and an expansion portion is arranged at each of two ends of the framework. The covered airway stent can be prevented from displacement in a trachea to a certain degree and is capable of preventing retention of airway secretion and meeting the seven requirements of a satisfactory airway stent completely, thereby being a product with practical value and popularization value.

Covered airway stent

Disclosed are an electrospun fibre-modified composite film and a preparation method therefor, falling within the field of biomedical materials. The electrospun fibre-modified composite film mainly complexes an electrospun fibre web film and a casting film, and regulates the mechanical properties and stability of the composite film by controlling the position and the number of layers of the fibre web film in the casting film. Compared with the traditional single polymer casting film material, the mechanical properties of the electrospun fibre-modified composite film of the present invention are significantly improved and the degradation rate thereof is controllable. The preparation method of the present invention is simple and has good repeatability, and the prepared electrospun fibre-modified composite film can be effectively applied to biomedical related fields, and has the possibility of broad clinical applications.

Electrospun fibre-modified composite film and preparation method therefor

The invention relates to a tracheal stent and application thereof. The tracheal stent comprises supporting rings and a supporting connecting rod, wherein the various supporting rings are of C-shaped structures and are serially connected by virtue of the supporting connecting rod, so that the various supporting rings are integrally fixed with the supporting connecting rod. The invention further provides a tissue engineering trachea, and the tissue engineering trachea is prepared by winding a chondrocyte-gelatin/polycaprolactone electrospun membrane complex on the outer surface of the tracheal stent. The tracheal stent or the tissue engineering trachea disclosed by the invention can be used for repairing tracheal stenosis by virtue of a tracheal external support suspension method, and a new C-shaped cartilaginous ring is formed after the implantation of the tracheal stent or the tissue engineering trachea, so as to guarantee growth potential finally.

Tracheal stent and application thereof

The utility model relates to a trachea support. The trachea support be equipped with support ring and support link, each the support ring be the C type, and each support ring is by the support link series connection to it is integrative become to make each support ring and support link fix. The utility model also provides an organizational project trachea, it be the exterior bread of trachea support make around cell - biodegradable materials compound membrane. Use the utility model discloses a trachea support or organizational project trachea, tracheal stenosis is repaired to the outer method of suspending in midair that supports of accessible trachea to form new C type cartilage ring after the implantation, finally make it to have the latent energy of to grow.

Trachea support and organizational project trachea

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Tracheal stent and application thereof

Trachea support and organizational project trachea