Han Ke

TL;DR: Cryogenic electron microscopy structures and G573S mutant structures reveal detailed ligand-binding sites, suggesting that Trpvicin inhibits the TRPV3 channel by stabilizing it in a closed state, and mechanistic insights into the inhibition of TRpV3 by TrPvicin are provided and support TRPv3-related drug development.

TL;DR: In this paper , a new chemo-enzymatic strategy for the diversity-oriented syntheses of functionalized cyclohexenes was proposed, which showed a 34-fold increase in catalytic efficiency, broad substrate scope, and good to perfect stereoselectivity.

TL;DR: This work provides a profound mechanistic insight into the enzymatic activities of Fhb7 and paves the way for further utilizing Fhb7-related enzymes in crop breeding and DON detoxification by synthetic biology.

TL;DR: Cryo-electron microscopy structures of human TRPV4 are presented in-complex with two potent antagonists, revealing the detailed binding pockets and regulatory mechanisms of TRPV4 gating and provide crucial mechanistic insights into TRPV4 regulation by small-molecule antagonists, which may facilitate future drug discovery targeting TRPV4.