The invention discloses a triazole CYP51-HDAC double-target antifungal compound, which has a structural general formula disclosed in the invention, wherein R is selected from one of the structures disclosed in the invention. According to the triazole CYP51-HDAC double-target antifungal compound disclosed by the invention, an HDAC inhibitor fragment is introduced into a traditional triazole drug structure; a series of CYP51-HDAC double-target inhibitors are obtained, and the CYP51-HDAC double-target inhibitors are effective to azole sensitive fungi, and more importantly, have excellent in-vitroand in-vivo activity to azole drug-resistant fungi.

Triazole CYP51-HDAC double-target antifungal compound as well as preparation method and application thereof

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Triazole CYP51-HDAC double-target antifungal compound as well as preparation method and application thereof