Han Geuk Seo
Konkuk University
181 Papers
1K Citations
Han Geuk Seo is an academic researcher from Konkuk University. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 42, co-authored 175 publications. Previous affiliations of Han Geuk Seo include Gyeongsang National University & Kyoto Prefectural University of Medicine.
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Papers
YS 49, 1-(α-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1
TL;DR: YS 49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity through the regulation of ROS production and JNK phosphorylation.
Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages.
Konstantin Tsoyi,Irina Tsoy Nizamutdinova,Hwa Jin Jang,Lidiya Mun,Hye Jung Kim,Han Geuk Seo,Jae Heun Lee,Ki Churl Chang +7 more
TL;DR: It is concluded that CO selectively inhibits iNOS over COX-2, at least through IFN&bgr;/JAK2/STAT1 signals, and this regulation plays an important role in the CORM-2-mediated inhibitory effect on HMGB1 release in macrophages.
Transforming Growth Factor-β1 Is a Molecular Target for the Peroxisome Proliferator-Activated Receptor δ
Hyo Jung Kim,Sun Ah Ham,Sung Uk Kim,Jin-Yong Hwang,Jae-Hwan Kim,Ki Churl Chang,Chihiro Yabe-Nishimura,Jin-Hoi Kim,Han Geuk Seo +8 more
TL;DR: The presence of a novel TGF-&bgr;1–mediated pathway in the antiinflammatory activities of PPAR&dgr; is demonstrated, whereas the expression of proinflammatory genes including monocyte chemoattractant protein-1 was significantly attenuated in the thoracic aorta.
Identification of a truncated alternative splicing variant of human PPARγ1 that exhibits dominant negative activity
Hyo Jung Kim,Im Sun Woo,Eun Sil Kang,So Young Eun,Hye Jung Kim,Jae Heun Lee,Ki Churl Chang,Jin-Hoi Kim,Han Geuk Seo +8 more
TL;DR: Overexpression of PPARgamma1(tr) protein in CHO cells greatly enhanced their proliferation and anchorage-independent colony growth on soft agar, demonstrating that PPARGamma1 (tr) is an important physiologic isoform of PPargamma that modulates cellular functions of PP ARgamma 1(wt).
Cationic lipid-nanoceria hybrids, a novel nonviral vector-mediated gene delivery into mammalian cells: investigation of the cellular uptake mechanism.
Joydeep Das,Jae Woong Han,Yun-Jung Choi,Hyuk Song,Ssang-Goo Cho,Chankyu Park,Han Geuk Seo,Jin-Hoi Kim +7 more
TL;DR: DODAB–nanoceria hybrids are developed as a new class of non-viral gene delivery vectors that could effectively compact the pDNA, allowing for highly efficient gene transfection into the selected cell lines and could transfect genes in vivo without any sign of toxicity.