Han Gao
Tongji University
17 Papers
36 Citations
Han Gao is an academic researcher from Tongji University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 4 publications.
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Papers
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Zhanju Liu,Ruize Liu,Han Gao,Xiang Gao,Ruicong Sun,Xiaoming Liu,Yong-joong Kim,Ho Su Lee,Yosuke Kawai,Masao Nagasaki,Junji Umeno,Katsushi Tokunaga,Yoshitaka Kinouchi,Atsushi Masamune,Wenzhao Shi,Zhenglin Guo,K. Yuan,Maria del Rosario Abreu,Jean-Paul Achkar,Vibeke Andersen,Charles Bernstein,Steven R. Brant,Luis Bujanda,Siew C. Ng,Lee A. Denson,Richard H. Duerr,Lynnette R. Ferguson,Denis Franchimont,Andre Franke,Richard B. Gearry,Hakon Hakonarson,Jonas Halfvarson,Caren Heller,Antonio Julià,Judith R. Kelsen,Hamed Khalili,Subra Kugathasan,Juozas Kupcinskas,Anna Latiano,Edouard Louis,Reza Malekzadeh,Jacob L. McCauley,David T. Okou,Timothy R. Orchard,Aarno Palotie,Miles Parkes,Joel Pekow,Uroš Potočnik,Graham L. Radford-Smith,John D. Rioux,Gerhard Rogler,Bruce E. Sands,Mark S. Silverberg,H. Sokol,Severine Vermeire,Rinse K. Weersma,Ramnik J. Xavier,Nai-Zhong Hu,Qian Cao,Yufang Wang,Yinglei Miao,Hongjie Zhang,Xiao-Ping Lv,Xiang Gao,Hui Zhang,Jingling Su,Baisui Feng,Ye Zhao,Liangru Zhu,Yan Chen,Lan Zhu,Chunxiao Chen,Yali Wang,Ying-De Wang,Zhi Pang,Yi Chen,Xiaolan Zhang,Hui Li,Qin Yu,Mei Ye,Sumin Zhang,Wen Tang,Mei Wang,Xiaocang Cao,Ruixin Zhu,Guangxi Zhou,Zhaolian Bian,Xiaofeng Guo,Xiaoli Wu,Jinchun Liu,Wei Xu,Yuqin Li,Qin Guo,Zhiguo Guo,Shu-Xia Zhu,Dalin Li,Jianjun Liu,Tian Ge,Judy H. Cho,Mark J. Daly,Dermot P.B. McGovern,Byong Duk Ye,Kyuyoung Song,Yoichi Kakuta,Mingsong Li,Hailiang Huang +105 more
TL;DR: The largest IBD study of individuals of East Asian (EAS) ancestries is reported, finding 80 IBD loci in EAS alone and 320 when meta-analyzed with ~370,000 EUR individuals, among which 81 are new.
77
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2
Ritian Lin,Wei Wu,Huimin Chen,Han Gao,Xiaohan Wu,Gengfeng Li,Qiong He,Huiying Lu,Mingming Sun,Zhanju Liu +9 more
TL;DR: It is pointed out that GPR65 promotes Th1 and Th17 cell immune response and intestinal mucosal inflammation by suppressing NUAK2 expression, and that targeting Gpr65 and NUak2 in CD4+ T cells may represent a novel therapeutic approach for IBD.
28
MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis
Huiying Lu,Cui Zhang,Wei Wu,Huimin Chen,Ritian Lin,Ruicong Sun,Xiang Gao,Gengfeng Li,Qiong He,Han Gao,Xiaohan Wu,Jian Lin,Ruixin Zhu,Jianli Niu,Pappachan E. Kolattukudy,Zhanju Liu +15 more
TL;DR: Macrophage-specific Mcpip1 deficiency polarises macrophages towards M1-like phenotype, arrests macrophage maturation and exacerbates intestinal inflammation in an Atf3-Ap1s2-dependent manner, thus providing novel mechanistic insight into intestinal macrophaging functions during IBD.
24
Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease
Xiang Gao,Ruicong Sun,Na Jiao,Xiao Liang,Gengfeng Li,Han Gao,Xiaohan Wu,Ming Yang,Chunqiu Chen,Xiaomin Sun,Liang Chen,Wei Wu,Yingzi Cong,Ruixin Zhu,Tiannan Guo,Zhanju Liu +15 more
TL;DR: In this paper , the authors profile the host proteins and tissue microbes in 540 samples from the intestinal mucosa, submucosa-muscularis-serosa, mesenteric adipose tissues, mesentery, and mesentic lymph nodes of 30 Crohn's disease patients and spatially decipher the host-microbial interactions.
23
Natural Herbal Remedy Wumei Decoction Ameliorates Intestinal Mucosal Inflammation by Inhibiting Th1/Th17 Cell Differentiation and Maintaining Microbial Homeostasis.
Xiaohan Wu,Huimin Chen,Xiang Gao,Han Gao,Qiong He,Gengfeng Li,Jun Yao,Zhanju Liu +7 more
TL;DR: WMD ameliorates chronic colitis in mice induced by DSS or reconstituted with CD45RBhighCD4+ T cells through suppressing Th1/Th17 cell differentiation and the secretion of proinflammatory cytokines, maintaining epithelial barrier function, and improving the dysbiosis.
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