6 Papers
4 Citations
Han Cao is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Medicine & Deep learning. The author has an hindex of 1, co-authored 2 publications.
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Papers
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
TL;DR: This study profiled 169,496 nuclei from the prefrontal cortical samples of AD patients and healthy controls by single-nucleus RNA sequencing, revealing a role of antigen presentation by angiogenic endothelial cells in AD and offering important insights into the therapeutic potential of targeting glial- and endothelial-specific pathways to restore brain homeostasis in AD.
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Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction
Xiaopu Zhou,Yu Chen,Fanny C.F. Ip,Yuanbing Jiang,Han Cao,Gengsi Lv,Huan-Qiong Zhong,Jiahang Chen,Tao Ye,Yuewen Chen,Yulin Zhang,Shuangshuang Ma,Ronnie M. N. Lo,Estella P.S. Tong,Michael W. Weiner,P. Aisen,Ronald C. Petersen,Clifford R. Jack,William J. Jagust,John Q. Trojanowski,Arthur W. Toga,Laurel A. Beckett,Robert C Green,Andrew J. Saykin,J.H. Morris,Leslie M. Shaw,Zaven S. Khachaturian,Greg Sorensen,Lew Kuller,Marcus E. Raichle,Steven M. Paul,Peter Davies,Howard Fillit,Franz Hefti,David M. Holtzman,M. Marcel Mesulam,William Z. Potter,Peter J. Snyder,Adam Schwartz,Thomas J. Montine,Ronald G. Thomas,Michael C. Donohue,Sarah Walter,Devon Gessert,Tamie Sather,Gus Jiminez,Danielle J Harvey,M S Bernstein,Paul M. Thompson,Norbert Schuff,Bret J. Borowski,Jeff Gunter,Matthew L. Senjem,Prashanthi Vemuri,David T.W. Jones,Kejal Kantarci,Chadwick P. Ward,Robert A. Koeppe,Norman L. Foster,Eric M. Reiman,Kewei Chen,Chet Mathis,Susan M. Landau,Nigel J. Cairns,Erin Householder,Lisa Taylor-Reinwald,Virginia M.-Y. Lee,Magdalena Korecka,Michal J. Figurski,Karen Crawford,Scott C. Neu,Tatiana Foroud,Steven G. Potkin,Li Shen,Kelley Faber,Sungeun Kim,Kwangsik Nho,L. Thal,Neil Buckholtz,M.S. Albert,Richard Frank,John K. Hsiao,Jeffrey Kaye,Joseph F. Quinn,Betty Lind,Raina Carter,Sara Dolen,Lon S. Schneider,Sonia Pawluczyk,Mauricio Beccera,Liberty Teodoro,Bryan M. Spann,James B. Brewer,Helen Vanderswag,Adam S. Fleisher,Judith L. Heidebrink,Joanne L. Lord,Sara S. Mason,Colleen S. Albers,David S. Knopman,Chris A. Johnson,Rachelle S. Doody,Javier Villanueva-Meyer,Munir Chowdhury,Susan Rountree,Mimi Dang,Yaakov Stern,Lawrence S. Honig,Karen L. Bell,Beau M. Ances,Maria Carroll,Sue Leon,Mark A. Mintun,Stacy Schneider,Angela Oliver,D G Marson,Randall Griffith,David Clark,David S. Geldmacher,John C. Brockington,Erik D. Roberson,Hillel Grossman,Effie M. Mitsis,Leyla de Toledo-Morrell,Raj C. Shah,Ranjan Duara,Daniel Varon,Maria T. Greig,Peggy Roberts,Chiadi U. Onyike,Daniel D'Agostino,Stephanie Kielb,James E. Galvin,Brittany Cerbone,Christina A. Michel,Henry Rusinek,Mony J. de Leon,Lidia Glodzik,Susan De Santi,P. Murali Doraiswamy,Jeffrey R. Petrella,Terence Z. Wong,Steven E. Arnold,Jason Karlawish,David A. Wolk,Charles D. Smith,G. Jicha,Peter Hardy,Partha Sinha,Elizabeth Oates,Gary R. Conrad,Oscar L. Lopez,MaryAnn Oakley,Donna M. Simpson,Anton P. Porsteinsson,Bonnie S. Goldstein,Kim Martin,Kelly M. Makino,M. Saleem Ismail,Connie Brand,Ruth A. Mulnard,Gaby Thai,Catherine McAdams-Ortiz,Kyle B. Womack,Dana Mathews,Mary Quiceno,Ramon F. Diaz-Arrastia,Richard D. King,M. Weiner,Kristen Martin-Cook,Michael D. Devous,Allan I. Levey,James J. Lah,Janet S. Cellar,Jeffrey M. Burns,Heather Anderson,Russell H. Swerdlow,Liana G. Apostolova,Kathleen Tingus,Ellen Woo,Daniel H.S. Silverman,Po H. Lu,George Bartzokis,Neill R. Graff-Radford,Francine Parfitt,Tracy Kendall,Heather E. Johnson,Martin R. Farlow,Ann Marie Hake,Brandy R. Matthews,Scott Herring,Cynthia Louise Lytle Hunt,Christopher H. van Dyck,Richard E. Carson,Martha G. MacAvoy,Howard Chertkow,Howard Bergman,Chris Hosein,Ging-Yuek Robin Hsiung,Howard Feldman,Benita Mudge,Michele Assaly,Charles Bernick,Donna Munic,Andrew Kertesz,John Rogers,Dick Trost,Diana R. Kerwin,Kristine Lipowski,Chuang Kuo Wu,Nancy Johnson,Carl H. Sadowsky,Walter Martinez,Teresa Villena,R. Scott Turner,Kathleen R. Johnson,Brigid Reynolds,Reisa A. Sperling,Keith A. Johnson,Gad A. Marshall,Meghan Frey,Barton Lane,Allyson C. Rosen,Jared R. Tinklenberg,Marwan N. Sabbagh,Christine Belden,Sandra W. Jacobson,Sherye A. Sirrel,Neil W. Kowall,Ronald J. Killiany,Andrew E. Budson,Alexander Norbash,Patricia Lynn Johnson,Joanne S. Allard,Alan J. Lerner,Paula Ogrocki,Leon Hudson,Evan Fletcher,Owen Carmichael,John M Olichney,Charles DeCarli,Smita Kittur,Michael Borrie,T. Lee,Robert Bartha,Sterling Johnson,Sanjay Asthana,Cynthia M. Carlsson,Adrian Preda,Dana Nguyen,Pierre N. Tariot,Stephanie Reeder,Vernice Bates,Horacio Capote,Michelle Rainka,Douglas W. Scharre,Maria Kataki,Anahita Adeli,Earl A. Zimmerman,Dzintra Celmins,Alice D. Brown,Godfrey D. Pearlson,Karen Blank,Karen E. Anderson,Robert B. Santulli,Tamar J. Kitzmiller,Eben S. Schwartz,Kaycee M. Sink,Jeff D. Williamson,Pradeep Garg,Franklin Watkins,Brian R. Ott,Henry W. Querfurth,Geoffrey Tremont,Stephen Salloway,Paul Malloy,Stephen Correia,Howard J. Rosen,Bruce L. Miller,Jacobo Mintzer,Kenneth M. Spicer,David Bachman,Stephen H. Pasternak,Irina Rachinsky,Dirk C. Drost,Nunzio Pomara,Raymundo Hernando,Antero Sarrael,Susan K. Schultz,Laura L. Boles Ponto,Hyungsub Shim,Karen E. Smith,Norman R. Relkin,Gloria Chaing,Lisa Raudin,Amanda Smith,Kristin Fargher,Balebail Ashok Raj,Thomas C. Neylan,Jordan Grafman,Melissa Davis,Rosemary H Morrison,Jacqueline Hayes,Shannon Rose Finley,K. J. Friedl,Debra A. Fleischman,Konstantinos Arfanakis,Olga James,Dino Massoglia,J. Jay Fruehling,Sandra Harding,Elaine R. Peskind,Eric C. Petrie,Gail Li,Jerome A. Yesavage,Joy L. Taylor,Ansgar J. Furst,Vincent Mok,Timothy Kwok,Qihao Guo,Kin Y. Mok,Maryam Shoai,John Hardy,Lei Chen,Amy K.Y. Fu,Nancy Y. Ip +325 more
TL;DR: In this article , a deep learning neural network model was proposed to predict polygenic risk of Alzheimer's disease. But, the model was not able to capture the complexity of genomic data, and current statistical analyses cannot comprehensively capture the polygenic risk of AD, resulting in unsatisfactory disease risk prediction.
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases.
Tao Ye,Yangyang Duan,Hayley W. S. Tsang,He Xu,Yuewen Chen,Yuewen Chen,Han Cao,Yu Chen,Yu Chen,Amy K.Y. Fu,Nancy Y. Ip +10 more
- 12 Feb 2021
TL;DR: In this paper, the authors demonstrate a simple and precise method to simultaneously generate iPSC lines with different gene dosages using paired Cas9 nickases, which enables the rapid and simultaneous generation of iPSCs with monoallelic, biallelic, or triallelic knockout of APP.
Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification.
Huan-Qiong Zhong,Xiaopu Zhou,Hyebin Uhm,Yuanbing Jiang,Han Cao,Yu Chen,Tiffany T W Mak,Ronnie M. N. Lo,Bonnie W.Y. Wong,E. Y. L. Cheng,Kin Y. Mok,Andrew Lung Tat Chan,Timothy C Y Kwok,Vincent C T Mok,Fanny C.F. Ip,John Hardy,Amy K.Y. Fu,Nancy Y. Ip +17 more
TL;DR: Blood transcriptome analysis accurately classifies and stratifies patients with Alzheimer's disease, with some gene modules achieving classification accuracy comparable to that of the plasma ATN biomarkers.
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Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer’s Disease Risk
Han Cao,Xiaopu Zhou,Yu Chen,Fanny C.F. Ip,Yuewen Chen,Nicole C. H. Lai,Ronnie M. N. Lo,Estella P.S. Tong,Vincent Mok,Timothy Kwok,Amy K.Y. Fu,Nancy Y. Ip +11 more
TL;DR: This study is the first to report a significant association of SPI1 with AD in the Chinese population and identifies SPI1 haplotypes that are associated with SPI1 gene expression and decreased AD risk.