Hamna Shahnawaz
University of Pennsylvania
2 Papers
Hamna Shahnawaz is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Reporter gene & T cell. The author has an hindex of 2, co-authored 2 publications.
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Papers
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs.
István Tombácz,Dorottya Laczkó,Hamna Shahnawaz,Hiromi Muramatsu,Ambika Natesan,Amir Yadegari,Tyler E. Papp,Mohamad-Gabriel Alameh,Vladimir V. Shuvaev,Barbara L. Mui,Ying K. Tam,Vladimir R. Muzykantov,Norbert Pardi,Drew Weissman,Hamideh Parhiz +14 more
TL;DR: In this article, the authors reported that conjugating CD4 antibody to LNPs enables specific targeting and mRNA interventions to CD4+ cells, including T lymphocytes, and demonstrated that the specific and efficient targeting and transfection of mRNA to T cells established in this study provides a platform technology for immunotherapy of devastating conditions and HIV cure.
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One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA.
Dapeng Zhang,Elena N. Atochina-Vasserman,Devendra S. Maurya,Ning Huang,Qi Xiao,Nathan Ona,Matthew Liu,Hamna Shahnawaz,Houping Ni,Kyunghee Kim,Margaret M. Billingsley,Darrin J. Pochan,Michael J. Mitchell,Drew Weissman,Virgil Percec +14 more
TL;DR: In this article, the authors developed a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement.
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