Halil Saglam
Uludağ University
62 Papers
249 Citations
Halil Saglam is an academic researcher from Uludağ University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 62 publications.
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Papers
Comprehensive Screening of Eight Known Causative Genes in Congenital Hypothyroidism With Gland-in-Situ.
Adeline K Nicholas,Eva Goncalves Serra,Hakan Cangul,Saif Al-Yaarubi,Irfan Ullah,Erik Schoenmakers,Asma Deeb,Abdelhadi M. Habeb,Mohammad S. Al-Maghamsi,Catherine Peters,Nisha Nathwani,Zehra Aycan,Halil Saglam,Ece Böber,Mehul T. Dattani,Savitha Shenoy,Philip Murray,Amir Babiker,Ruben H. Willemsen,Ajay Thankamony,Greta Lyons,Rachael Irwin,Raja Padidela,Raja Padidela,Kavitha Tharian,Justin H Davies,Vijith Puthi,Soo-Mi Park,Ahmed F. Massoud,John Gregory,Assunta Albanese,Evelien Pease-Gevers,Howard Martin,Kim Brügger,Eamonn R. Maher,V. Krishna K. Chatterjee,Carl A. Anderson,Nadia Schoenmakers +37 more
TL;DR: The etiology of CH with GIS remains elusive, with only 59% attributable to mutations in TSHR or known dyshormonogenesis-associated genes in a cohort enriched for familial cases.
Thyroid dyshormonogenesis is mainly caused by TPO mutations in consanguineous community
Hakan Cangul,Hakan Cangul,Zehra Aycan,Álvaro Olivera-Nappa,Halil Saglam,Nadia Schoenmakers,Kristien Boelaert,Semra Çetinkaya,Ömer Tarım,Ece Böber,Feyza Darendeliler,Veysel Nijat Baş,Korcan Demir,Banu Kucukemre Aydin,Michaela Kendall,Trevor Cole,Wolfgang Högler,V. Krishna K. Chatterjee,Timothy Barrett,Eamonn R. Maher +19 more
TL;DR: This study aimed to investigate the genetic background of thyroid dyshormonogenesis (TDH), and found that iodine deficiency in women is a major cause of thyroid disease.
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Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.
Hakan Cangul,Xiao Hui Liao,Erik Schoenmakers,Jukka Kero,Sharon Barone,Panudda Srichomkwun,Hideyuki Iwayama,Eva Goncalves Serra,Halil Saglam,Erdal Eren,Ömer Tarım,Adeline K Nicholas,Ilona Zvetkova,Carl A. Anderson,Fiona E. Karet Frankl,Kristien Boelaert,Marja Ojaniemi,Jarmo Jääskeläinen,Konrad Patyra,Christoffer Löf,E. Dillwyn Williams,Manoocher Soleimani,Timothy Barrett,Eamonn R. Maher,V. Krishna K. Chatterjee,Samuel Refetoff,Nadia Schoenmakers +26 more
TL;DR: In this paper, homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous hypothyroidism also occurs in Slc26a7-null mice.
Meropenem decreases serum level of valproic acid
TL;DR: It is clear that concomitant meropenem administration decreases serum valproic acid concentration, and it is believed that there may be no need to change the antiepileptic drug during this period, provided that the patient has no seizure.
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Turner Syndrome and Associated Problems in Turkish Children: A Multicenter Study
Ediz Yeşilkaya,Abdullah Bereket,Feyza Darendeliler,Firdevs Bas,Sukran Poyrazoglu,Banu Kucukemre Aydin,Şükran Darcan,Bumin Dündar,Muammer Buyukinan,Cengiz Kara,Erkan Sari,Erdal Adal,Ayşehan Akıncı,Mehmet Emre Atabek,Fatma Demirel,Nurullah Çelik,Behzat Özkan,Bayram Özhan,Zerrin Orbak,Betül Ersoy,Murat Doğan,Ali Ataş,Serap Turan,Damla Gökşen,Ömer Tarım,Bilgin Yüksel,Oya Ercan,Şükrü Hatun,Enver Simsek,Ayşenur Ökten,Ayhan Abaci,Hakan Doneray,Mehmet Nuri Ozbek,Mehmet Keskin,Hasan Önal,Nesibe Akyürek,Kezban Bulan,Derya Tepe,Hamdi Cihan Emeksiz,Korcan Demir,Deniz Özalp Kızılay,Ali Kemal Topaloglu,Erdal Eren,Samim Özen,Saygin Abali,Leyla Akin,Beray Selver Eklioğlu,Sultan Kaba,Ahmet Anık,Serpil Bas,Tolga Ünüvar,Halil Saglam,Semih Bolu,Tolga Özgen,Durmuş Doğan,Esra Deniz Çakır,Yaşar Şen,Nesibe Andiran,Filiz Mine Çizmecioğlu,Olcay Evliyaoğlu,Gülay Karagüzel,Ozgur Pirgon,Gönül Çatlı,Hatice Dilek Can,Fatih Gurbuz,Cigdem Binay,Veysel Nijat Baş,Kursat Fidanci,Adem Polat,Davut Gül,Cengizhan Açıkel,Huseyin Demirbilek,Peyami Cinaz,Carolyn Bondy +73 more
TL;DR: The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan.