Haley Halasz
University of California, Santa Cruz
9 Papers
9 Citations
Haley Halasz is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 3 publications.
Chat about Author
Papers
High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways.
Sergio Covarrubias,Apple Cortez Vollmers,Allyson Capili,Michael Boettcher,Aaron Shulkin,Michele Ramos Correa,Haley Halasz,Elektra K. Robinson,Laura O’Briain,Christopher Vollmers,James Blau,Sol Katzman,Michael T. McManus,Susan Carpenter +13 more
TL;DR: A high-throughput, pooled-based CRISPR-Cas screening approach is used to identify essential genes required for macrophage viability, and 3′ UTRs are targeted to gain insights into previously unidentified cis-regulatory regions that control these essential genes.
32
LincRNA-Cox2 functions to regulate inflammation in alveolar macrophages during acute lung injury
Elektra K. Robinson,Atesh Worthington,Donna M. Poscablo,Barbara Shapleigh,Mays Mohammed Salih,Haley Halasz,Lucas Seninge,Benny Mosqueira,Valeriya Smaliy,E. Camilla Forsberg,Susan Carpenter +10 more
TL;DR: In this article, the role of lincRNA-Cox2 in host defense was investigated using RNA-seq and florescence activated cell sorting in alveolar macrophages.
Epigenomic reprogramming of repetitive noncoding RNAs and IFN-stimulated genes by mutant KRAS
Roman E. Reggiardo,Maroli Sv,Haley Halasz,Mehmet Ozgun Ozen,Carrillo D,Erin LaMontagne,Lila Whitehead,Eejung Kim,Malik S,Jason D Fernandes,Georgi K. Marinov,Collisson E,Utkan Demirci,Daniel H. Kim +13 more
TL;DR: The results reveal that mutant KRAS remodels the noncoding transcriptome through epigenomic reprogramming, expanding the scope of genomic elements regulated by this fundamental signaling pathway and revealing how mutantKRAS induces an intrinsic IFN-stimulated gene signature often seen in ADAR-dependent cancers.
CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling.
Haley Halasz,Eric Malekos,S. Covarrubias,Samira Yitiz,Christy Montano,Lisa Sudek,Solomon Katzman,S. J. Liu,Max A. Horlbeck,Leila Namvar,Jonathan S Weissman,Susan Carpenter +11 more
TL;DR: CRISPRi screens identify the lncRNA LOUP as a multifunctional regulator of macrophage differentiation and inflammatory signaling. LOUP regulates the neighboring gene SPI1 and negatively regulates TLR4/NFkB signaling.
6
Challenges and Future Directions for LncRNAs and Inflammation.
Haley Halasz,Susan Carpenter +1 more
TL;DR: In this paper , the authors discuss the current state of the field of non-coding RNA therapeutics and how it may evolve to overcome the short cummings we currently face with diagnosing and treating inflammatory diseases.
6