Haiyun Wang
University of Iowa
14 Papers
258 Citations
Haiyun Wang is an academic researcher from University of Iowa. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 13, co-authored 14 publications. Previous affiliations of Haiyun Wang include Population Council.
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Papers
Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization
TL;DR: It is demonstrated that hormonal regulation of LH/CG receptor mRNA in rat ovarian cells parallels changes in LH/ CG receptor levels and involves diverse molecular mechanisms, including low concentrations of cAMP (elicited by FSH) in developing follicles, and inhibition by high concentrations of CAMP in PO follicles and induction and maintenance by PRL in corpora lutea of gestation.
Multiple Luteinizing Hormone/Chorionic Gonadotropin Receptor Messenger Ribonucleic Acid Transcripts*
TL;DR: The sizes and relative abundancies of gonadal LH/CG receptor transcripts are quite variable between such closely related species as rat and mouse, and the most abundant LH/ CG receptor mRNA present in MA-10 cells, a clonal strain of cultured Leydig tumor cells, is a 1.2 kilobase transcript.
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Intracellular retention of mutant gonadotropin receptors results in loss of hormone binding activity of the follitropin receptor but not of the lutropin/choriogonadotropin receptor.
TL;DR: It is concluded that substitution of D404 of the rFSHR prevents hormone binding as a result of the intracellular retention of the mutants in the endoplasmic reticulum presumably in an incompletely folded state, as opposed to disruption of a hormone-binding site at D404.
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The 5'-flanking region of the rat luteinizing hormone/chorionic gonadotropin receptor gene confers Leydig cell expression and negative regulation of gene transcription by 3',5'-cyclic adenosine monophosphate.
TL;DR: These studies show, for the first time, that sequence(s) present with 1370 base pairs of the translational start site of the rat LH/ CG receptor gene are sufficient for conferring expression of this gene in Leydig cells and for the negative modulation of LH/CG receptor gene transcription by high concentrations of cAMP.
The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors.
TL;DR: The results presented here show that this single point mutation of the LH/CG receptor leads to a slight reduction in affinity for hCG and oLH but completely abolishes the effects of Na+ removal on the affinity for oLLH.
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