Haixia Chen
Guangzhou Medical University
8 Papers
Haixia Chen is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Pulmonary hypertension & Medicine. The author has an hindex of 2, co-authored 5 publications.
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Papers
Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats
Chenting Zhang,Wenju Lu,Xiaoyun Luo,Shiyun Liu,Yi Li,Qiuyu Zheng,Qiuyu Zheng,Liu Wenyan,Xuefen Wu,Yuqin Chen,Qian Jiang,Zizhou Zhang,Guoping Gu,Jiyuan Chen,Jiyuan Chen,Haixia Chen,Jing Liao,Chunli Liu,Cheng Hong,Haiyang Tang,Dejun Sun,Kai Yang,Jian Wang,Jian Wang +23 more
TL;DR: Pulmonary veno‐occlusive disease is a rare disease characterized by the obstruction of small pulmonary veins leading to pulmonary hypertension, however, the mechanisms underlying pulmonary vessel occlusion remain largely unclear.
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SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells
Kai-Chien Yang,Shiyun Liu,Han Yan,Wenju Lu,Haixia Chen,Changlei Bao,Huazhuo Feng,Jing Liao,Shuxin Liang,Li Xu,Haiyang Tang,Jason X.-J. Yuan,Nanshan Zhong,Jian Wang +13 more
TL;DR: Findings provide compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering [Ca^2+]_i through upregulation of Piezo1 and Orai1 and Targeted inhibition of ACE2-Piezo1/SOCC-[Ca^1+]-i axis proves a powerful strategy to treat S- RBD-induced pulmonary vascular diseases.
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A novel rat model of pulmonary hypertension induced by mono treatment with SU5416.
Yuqin Chen,Meidan Kuang,Shiyun Liu,Chi Hou,Xin Duan,Kai Yang,Wenjun He,Jing Liao,Qiuyu Zheng,Guofa Zou,Haixia Chen,Han Yan,Jiyuan Chen,Yi Li,Ying Zhou,Xiaoyun Luo,Qian Jiang,Haiyang Tang,Wenju Lu,Jian Wang,Jian Wang +20 more
TL;DR: Treatment with SU5416 alone plus 5 weeks of normoxia could be sufficient to induce PH in rats, which may provide a good and convenient model for future investigation of PH.
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Sodium Tanshinone IIA Sulfonate Enhances the BMP9-BMPR2-Smad1/5/9 Signaling Pathway in Rat Pulmonary Microvascular Endothelial Cells and Human Embryonic Stem Cell-derived Endothelial Cells.
Jian Wang,Wenyan Liu,Wenju Lu,Xiaoyun Luo,Yong Lin,Shiyun Liu,Jing Qian,Chenting Zhang,Haixia Chen,Yi Li,Xiang Li,Jiyuan Chen,Yuqin Chen,Qian Jiang,Chunli Liu,Cheng Hong,Tao Wang,Haiyang Tang,Nanshan Zhong,Jun Yang,Kai-Chien Yang,Dejun Sun +21 more
TL;DR: In this paper , the effects and mechanisms of STS on pulmonary vascular endothelial dysfunction were investigated using a chronic hypoxia-induced pulmonary hypertension (HPH) rat model, as well as in primarily cultured rat PMVECs and human ESC-ECs cell models.
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Structural and functional definition of the pulmonary vein system in a chronic hypoxia-induced pulmonary hypertension rat model.
Xiongting Wu,Wenju Lu,Mengzhang He,Haixia Chen,Yuqin Chen,Xin Duan,Qiuyu Zheng,Yi Li,Jiyuan Chen,Shiyun Liu,Jing Liao,Meidan Kuang,Ziying Lin,Kai Yang,Jian Wang,Jian Wang +15 more
TL;DR: Investigation of the structural and functional changes in the PV isolated from the chronic hypoxia-induced PH rat model showed that CH caused an increase in right ventricular pressure, but did not affect the mean pulmonary venous pressure and the left atrial pressure, and fundamental data provided fundamental data to comprehensively define the PV system in CHPH rat model.
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