Haiping Hao
China Pharmaceutical University
297 Papers
1K Citations
Haiping Hao is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 50, co-authored 267 publications. Previous affiliations of Haiping Hao include Delaware Biotechnology Institute & Nanjing University of Chinese Medicine.
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Papers
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Fei Li,Changtao Jiang,Kristopher W. Krausz,Yunfei Li,Istvan Albert,Haiping Hao,Kristin M. Fabre,James B. Mitchell,Andrew D. Patterson,Andrew D. Patterson,Frank J. Gonzalez +10 more
TL;DR: A biochemical link between the microbiome, nuclear receptor signalling and metabolic disorders, and suggest that inhibition of FXR in the intestine could be a target for anti-obesity drugs are demonstrated.
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
Kai Deng,Mihaela Pertea,Anthony Rongvaux,Leyao Wang,Christine M. Durand,Gabriel Ghiaur,Jun Lai,Holly McHugh,Haiping Hao,Hao Zhang,Joseph B. Margolick,Cagan Gurer,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Steven G. Deeks,Till Strowig,Priti Kumar,Janet D. Siliciano,Steven L. Salzberg,Richard A. Flavell,Liang Shan,Robert F. Siliciano +22 more
TL;DR: It is demonstrated that chronically infected patients retain a broad-spectrum viral-specific CTL response and that appropriate boosting of this response may be required for the elimination of the latent reservoir of HIV-1.
Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis
Haiping Hao,Lijuan Cao,Changtao Jiang,Changtao Jiang,Yuan Che,Song-Yang Zhang,Song-Yang Zhang,Shogo Takahashi,Guangji Wang,Frank J. Gonzalez +9 more
TL;DR: It is shown that bile acids are danger-associated molecular patterns (DAMPs) that can activate both signal 1 and 2 of the NLRP3 inflammasome in inflammatory macrophages and that targeting FXR may represent a therapeutic strategy for cholestasis-associated sepsis.
360
Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.
Ross A. Pollack,R. Brad Jones,Mihaela Pertea,Katherine M. Bruner,Alyssa R. Martin,Allison S. Thomas,Adam A. Capoferri,Adam A. Capoferri,Subul A. Beg,Subul A. Beg,Szu-Han Huang,Sara Karandish,Haiping Hao,Eitan Halper-Stromberg,Patrick C. Yong,Colin Kovacs,Erika Benko,Robert F. Siliciano,Robert F. Siliciano,Ya Chi Ho +19 more
TL;DR: It is shown that defective proviruses can be transcribed into RNAs that are spliced and translated, and cells with defective major splice donors can be recognized by HIV-1-specific cytotoxic T lymphocytes (CTLs).
328
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
Danyu Du,Jing Xiong,Kenichi Sasaki,Chan Liu,Mengyao Qin,Xiao Zhang,Tao Xi,Shengtao Yuan,Haiping Hao,Jing Xiong +9 more
TL;DR: In this paper, the metabolic targets in glucose, fatty acid, amino acid and glutamine metabolism, which are suitable for hepatocellular carcinoma (HCC) pharmaceutical intervention are highlighted.
307