Haijun Zhong
Nanchang University
8 Papers
Haijun Zhong is an academic researcher from Nanchang University. The author has contributed to research in topics: Chemistry & Legumain. The author has an hindex of 5, co-authored 8 publications.
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Papers
Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide (Sec)
Siqi Zhu,Shuangxi Chen,Yuan Gao,Feng Guo,Fengying Li,Baogang Xie,Jianliang Zhou,Haijun Zhong +7 more
TL;DR: Using insulin as the model drug, in vivo studies performed on rats indicated that the relative bioavailability of insulin for Sec-Pen-NPs was 1.71-times increased after ileal segments administration, and stronger hypoglycemic effects was also observed, suggesting the nanoparticles co-modified with penetratin and Sec could act as attractive carriers for oral delivery of insulin.
67
Self-microemulsifying Drug Delivery System for Improved Oral Bioavailability of Dipyridamole: Preparation and Evaluation
TL;DR: It was evident that SMEDDS may be an effective approach to improve the oral absorption for drugs having pH-dependent solubility.
44
Legumain protease-sheddable PEGylated, tuftsin-modified nanoparticles for selective targeting to tumor-associated macrophages
De-Sheng Liang,Zu-Jun Wen,Jia-Hui Wang,Fang-Fang Zhu,Feng Guo,Jianliang Zhou,Jianjun Xu,Haijun Zhong +7 more
TL;DR: In this paper, the authors constructed a novel tumor-associated macrophage (TAM) target for anticancer therapy, which is an attractive cell target for antimalignancy therapy.
6
Solid lipid nanoparticles modified with amphipathic chitosan derivatives for improved stability in the gastrointestinal tract
Suping Qiu,De-Sheng Liang,Feng Guo,Tiantian Deng,Taoxing Peng,Yuan Gao,Xiuying Zhang,Haijun Zhong +7 more
TL;DR: In this article, two comb-shaped amphiphilic macromolecular materials of N-stearyl-N-trimethyl chitosan (STMC) and N-linoleoyl-Ntrimethyltransmethyl chitosaan (LTMC) were fabricated as emulsifier to modify SLNs.
5
Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation.
TL;DR: In this paper, modified nanoparticles with cell-penetrating peptide (Tat) and amphipathic chitosan derivative (a-CS) were used as carriers to improve colonic absorption of the drug.