Haig H. Kazazian
Johns Hopkins University School of Medicine
319 Papers
4.2K Citations
Haig H. Kazazian is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Gene & Retrotransposon. The author has an hindex of 98, co-authored 315 publications. Previous affiliations of Haig H. Kazazian include University of Pennsylvania & Post Graduate Institute of Medical Education and Research.
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Papers
•Journal Article
Pathogenic Orphan Transduction Created by a Non-reference LINE-1 Retrotransposon
Adam D. Ewing,Dustin C. Hancks,Yasuhiro Takeshima,Hiroyuki Awano,Masafumi Matsuo,Haig H. Kazazian,Szilvia Solyom +6 more
TL;DR: It is demonstrated that a nonreference full‐length LINE‐1 is situated in the proband and maternal genome at chromosome 11q22.3, directly upstream of the sequence, whose copy was inserted into the dystrophin gene.
Striking heterogeneity of somatic L1 retrotransposition in single normal and cancerous gastrointestinal cells
Katsumi Yamaguchi,Alisha O. Soares,Loyal A. Goff,Anjali Talasila,Jungbin A. Choi,Daria Ivenitsky,Sadik Karma,Benjamin Brophy,Scott E. Devine,Stephen J. Meltzer,Haig H. Kazazian +10 more
TL;DR: The number of L1 insertions in tumors of the same type is highly variable, and under certain conditions, somatic L1 retrotransposition exhibits a propensity for occurring in aneuploid cells.
A mouse model of human L1 retrotransposition
Eric M. Ostertag,Ralph J. DeBerardinis,John L. Goodier,Yue Zhang,Nuo Yang,George L. Gerton,Haig H. Kazazian +6 more
TL;DR: It is shown that L1 elements can retrotranspose in male germ cells, and that expression of a human L1 element under the control of its endogenous promoter is restricted to testis and ovary.
Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans
Adam D. Ewing,Haig H. Kazazian +1 more
TL;DR: This article presents evidence for 1016 L1 insertions across all studies to date that are not represented in the reference human genome assembly, many of which appear to be specific to populations or groups of populations, particularly Africans.
Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion
TL;DR: Assay in living and fixed cells tagged-RNPs generated from constructs expressing retrotransposition-competent L1s demonstrates for the first time the subcellular colocalization of L1 RNA and proteins ORF1p and ORF2p, and shows their targeting together to cytoplasmic foci.