Haig H. Kazazian
Johns Hopkins University School of Medicine
319 Papers
4.2K Citations
Haig H. Kazazian is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Gene & Retrotransposon. The author has an hindex of 98, co-authored 315 publications. Previous affiliations of Haig H. Kazazian include University of Pennsylvania & Post Graduate Institute of Medical Education and Research.
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Papers
Transduction of 3′-flanking sequences is common in L1 retrotransposition
TL;DR: L1 retrotransposition in vivo commonly transduces sequence flanking the 3' end of the element, and may have enlarged the diploid human genome as much as 19 Mb or 0.6% since there are approximately 400 000 L1 elements.
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A.
Ingrid Hrachovinova,Béatrice Cambien,Ali Hafezi-Moghadam,János Kappelmayer,Raymond T Camphausen,Angela Widom,Lijun Xia,Haig H. Kazazian,Robert G. Schaub,Rodger P. McEver,Denisa D. Wagner +10 more
TL;DR: P-sel–Ig treatment could become a new approach to sustained control of bleeding in hemophilia by inducing formation of procoagulant microparticles in human blood through P-selectin glycoprotein ligand-1 (PSGL-1; encoded by the Psgl1 gene, officially known as Selpl).
In vitro screening for compounds that enhance human L1 mobilization.
Natsuko Terasaki,John L. Goodier,Ling E. Cheung,Yue J. Wang,Masaki Kajikawa,Haig H. Kazazian,Norihiro Okada,Norihiro Okada +7 more
TL;DR: The results suggest that certain chemical- and drug-induced stresses might have the potential to cause genomic mutations by inducing L1 mobilization, and should be considered during drug safety evaluation and environmental risk assessments of chemicals.
An actively retrotransposing, novel subfamily of mouse L1 elements
Thierry Naas,Ralph J. DeBerardinis,John V. Moran,Eric M. Ostertag,Stephen F. Kingsmore,Michael F. Seldin,Yoshihide Hayashizaki,Sandra L. Martin,Haig H. Kazazian +8 more
TL;DR: The data indicate that the TF subfamily of L1s contains a major class of mobile elements that is expanding in the mouse genome, and is likely intermediates in retrotransposition.
L1 retrotransposition in nondividing and primary human somatic cells
Shuji Kubo,Maria del Carmen Seleme,Harris S. Soifer,José Luis Garcia Perez,John V. Moran,Haig H. Kazazian,Noriyuki Kasahara +6 more
TL;DR: Data indicate that L1 retrotransposition can occur in nondividing somatic cells and shows that the expression of a highly active human L1 element from an adenovirus-L1 hybrid vector can be suppressed by the reverse transcriptase inhibitor 3'-azido-3'-deoxythymidine.