Hager Mansour
Okayama University
10 Papers
9 Citations
Hager Mansour is an academic researcher from Okayama University. The author has contributed to research in topics: Cancer stem cell & Induced pluripotent stem cell. The author has an hindex of 5, co-authored 7 publications.
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Papers
A novel model of liver cancer stem cells developed from induced pluripotent stem cells.
Said M. Afify,Said M. Afify,Anna Sanchez Calle,Ghmkin Hassan,Ghmkin Hassan,Kazuki Kumon,Hend M. Nawara,Maram H. Zahra,Hager Mansour,Apriliana Cahya Khayrani,Jahangir Alam,Juan Du,Akimasa Seno,Yoshiaki Iwasaki,Masaharu Seno,Masaharu Seno +15 more
TL;DR: A model of liver CSCs converting from miPS is established and showed different stages of stemness during conversion process, which will be important to assess the molecular mechanisms necessary to develop liver C SCs and could help in defeating liver cancer.
Metastasis of Cancer Stem Cells Developed in the Microenvironment of Hepatocellular Carcinoma
Said M. Afify,Said M. Afify,Ghmkin Hassan,Amira Osman,Anna Sanchez Calle,Hend M. Nawara,Maram H. Zahra,Samah El-Ghlban,Samah El-Ghlban,Hager Mansour,Jahangir Alam,Hagar A. Abu Quora,Juan Du,Akimasa Seno,Yoshiaki Iwasaki,Masaharu Seno,Masaharu Seno +16 more
TL;DR: The CSCs derived from iPSCs, forming malignant tumors and displaying high metastasis, will provide a good animal model to study the mechanisms of metastasis.
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Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells
Ghmkin Hassan,Ghmkin Hassan,Said M. Afify,Said M. Afify,Neha Nair,Kazuki Kumon,Amira Osman,Amira Osman,Juan Du,Hager Mansour,Hagar A. Abu Quora,Hend M. Nawara,Ayano Satoh,Maram H. Zahra,Nobuhiro Okada,Akimasa Seno,Akimasa Seno,Masaharu Seno,Masaharu Seno +18 more
TL;DR: CSCs were demonstrated to have the potential to provide progenies with hematopoietic markers, morphology, and homing ability to the bone marrow, which could give new insight into the tumor microenvironment according to the plasticity of CSCs.
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Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment
Juan Du,Yanning Xu,Saki Sasada,Aung Ko Ko Oo,Ghmkin Hassan,Ghmkin Hassan,Hafizah Mahmud,Apriliana Cahya Khayrani,Apriliana Cahya Khayrani,Jahangir Alam,Kazuki Kumon,Ryo Uesaki,Said M. Afify,Said M. Afify,Hager Mansour,Neha Nair,Maram H. Zahra,Akimasa Seno,Akimasa Seno,Nobuhiro Okada,Ling Chen,Ting Yan,Masaharu Seno +22 more
TL;DR: Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of miPSCs into CSCs in the tumor microenvironment.
Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells.
Hend M. Nawara,Said M. Afify,Said M. Afify,Ghmkin Hassan,Ghmkin Hassan,Maram H. Zahra,Marwa N. Atallah,Hager Mansour,Hagar A. Abu Quora,Hagar A. Abu Quora,Jahangir Alam,Jahangir Alam,Amira Osman,Hiroki Kakuta,Hiroki Hamada,Akimasa Seno,Masaharu Seno +16 more
TL;DR: The results suggest the combination therapy of paclitaxel and sorafenib in low doses should be an attractive approach to target cancer stem cells with fewer side effects.