Hadas Lewinsky
Weizmann Institute of Science
15 Papers
7 Citations
Hadas Lewinsky is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Biology & Chronic lymphocytic leukemia. The author has an hindex of 5, co-authored 11 publications.
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Papers
CD74 is a novel transcription regulator
Naama Gil-Yarom,Lihi Radomir,Lital Sever,Matthias P. Kramer,Hadas Lewinsky,Chamutal Bornstein,Ronnie Blecher-Gonen,Zohar Barnett-Itzhaki,Vita Mirkin,Gilgi Friedlander,Lev Shvidel,Yair Herishanu,Elias Lolis,Shirly Becker-Herman,Ido Amit,Idit Shachar +15 more
TL;DR: It is demonstrated that CD74’s cytoplasmic domain binds chromatin and regulates transcription and expression of genes involved in immune regulation, cell survival, and hematopoietic cancers and that identifying targets of CD74 will help in understanding of essential pathways regulating B-cell survival in health and disease.
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CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia
Hadas Lewinsky,Avital F. Barak,Victoria Huber,Matthias P. Kramer,Lihi Radomir,Lital Sever,Irit Orr,Vita Mirkin,Nili Dezorella,Mika Shapiro,Yosef Cohen,Lev Shvidel,Martina Seiffert,Yair Herishanu,Shirly Becker-Herman,Idit Shachar +15 more
TL;DR: A role for CD84 is demonstrated in the regulation of immune checkpoints by leukemia cells and CD84 blockade is identified as a therapeutic strategy to reverse tumor-induced immune suppression.
The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
Lihi Radomir,Matthias P. Kramer,Michal Perpinial,Nofar Schottlender,Stav Rabani,Keren David,Anna Wiener,Hadas Lewinsky,Shirly Becker-Herman,Rina Aharoni,Ron Milo,Claudia Mauri,Idit Shachar +12 more
TL;DR: In this article, the authors identify SLAMF5 for controlling IL-10+ Breg maintenance and function, and demonstrate that blocking SLAMf5 in vitro induces both human and mouse IL10-producing Breg cells and increases their survival with a concomitant increase of a transcription factor, c-Maf.
CD74 as a regulator of transcription in normal B cells.
K. David,Gilgi Friedlander,Bianca Pellegrino,Lihi Radomir,Hadas Lewinsky,Lin Leng,Richard Bucala,Shirly Becker-Herman,Idit Shachar +8 more
TL;DR: In this paper , the authors investigated the transcriptional and regulatory function of CD74-ICD in normal B cells and showed that following activation, CD74ICD forms a complex in the cytosol with transcription factors, like PAX5, and binds the chromatin at a significantly higher number of sites compared with its binding in CLL cells.
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CD84 mediates CLL-microenvironment interactions
Ayelet Marom,Avital F. Barak,Matthias P. Kramer,Hadas Lewinsky,Inbal Binsky-Ehrenreich,Sivan Cohen,A Tsitsou-Kampeli,Vyacheslav Kalchenko,Yuri Kuznetsov,Vita Mirkin,Nili Dezorella,Mika Shapiro,Pamela L. Schwartzberg,Yosef Cohen,Lev Shvidel,Michal Haran,Shirly Becker-Herman,Yair Herishanu,Idit Shachar +18 more
TL;DR: In vitro results show that CD84 expression on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides, and suggest novel therapeutic strategies based on the blockade of this CD84-dependent survival pathway.
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