H. van Ormondt
Leiden University
51 Papers
2.2K Citations
H. van Ormondt is an academic researcher from Leiden University. The author has contributed to research in topics: Gene & DNA. The author has an hindex of 28, co-authored 51 publications. Previous affiliations of H. van Ormondt include Leiden University Medical Center.
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Papers
Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.
Domenico Valerio,M. G. C. Duyvesteyn,B.M.M. Dekker,G. Weeda,Th.M. Berkvens,L. Van Der Voorn,H. van Ormondt,A. J. Van Der Eb +7 more
TL;DR: Cosmid clones containing the gene for human adenosine deaminase (ADA) were isolated and it was shown in a functional assay that a stretch of 135 bp immediately preceding the cap site has promoter activity.
314
The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets
Johannes L. Bos,L.J. Polder,René Bernards,P.I. Schrier,P.J. van den Elsen,A. J. Van Der Eb,H. van Ormondt +6 more
TL;DR: Peptide mapping shows that the small and large tumor antigens do not share common tryptic peptides, in accordance with the nucleic acid sequence data.
285
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position.
TL;DR: The data showed that inactivation of the Mo-MuLV LTR is a frequent event in murine fibroblast cell lines, inactivation is associated with de novo methylation of cytidine residues, the frequency of in activation of the provirus must be determined by its chromosomal position, and the process ofmethylation of sequences within the L TR is not necessarily the same as the transcription-repression mechanism that is operating in undifferentiated embryonal carcinoma cells.
176
•Journal Article
Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells
Shi-Mei Zhuang,A. Shvarts,H. van Ormondt,Aart G. Jochemsen,A. J. Van Der Eb,Mathieu H.M. Noteborn +5 more
TL;DR: The fact that apoptin can induce p53-independent apoptosis in human tumor cells makes apoptin a potential candidate for treatment of frequently occurring types of cancer cells that do not contain functional p53.
160
The nucleotide sequence of the transforming HpaI-E fragment of adenovirus type 5 DNA
TL;DR: The identification of potential initiation and termination codons in the determined sequence indicates that two small polypeptides consisting of 186, and 81 amino acids, respectively, could be synthesized.
152