https://www.amjmed.com/article/0002-9343(59)90173-1/pdf

Serum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systems. A consideration of the current status.

Manifestations of metastatic tumors of the liver. A study of eighty-one patients subjected to needle biopsy.

Radioisotope Photoscanning of the Liver

A sensitive and economic method of screening for liver metastases in patients with colorectal cancer was developed using serum alkaline phosphatase and carcinoembryonic antigen. The upper limit of normal for alkaline phosphatase and carcinoembryonic antigen did not represent the optimal levels for use in predicting liver metastases. However, with alkaline phosphatase greater than 135 I.U., and/or carcinoembryonic antigen greater than 10 ng/ml, sensitivity was 88%: 23 of 26 patients with liver metastases fulfilled either or both criteria. The false-positive rate was 12%. Liver scanning, alone, demonstrated metastases in only 69% of 35 patients with liver metastases. The combination of alkaline phosphatase and carcinoembryonic antigen can be used economically to screen for liver metastases, and to determine which patients should undergo a liver scan.

Screening for liver metastases from colorectal cancer with carcinoembryonic antigen and alkaline phosphatase.

In 11 patients with a histological diagnosis of liver tumor, the 5′-nucleotidase was elevated in each case Only 6 of these patients showed an increase of the serum alkaline phosphatase, which was always of a smaller magnitude than the elevation of the 5′-nucleotidase In 6 patients with an unequivocal isotope liver scan for metastatic tumor without positive tissue diagnosis 2 patients showed elevations of both enzymes; 2 patients showed slight elevation of the 5′-nucleotidase with no change in the alkaline phosphatase and 2 patients showed no change in either enzyme These data suggest that the serum 5′-nucleotidase shows a greater sensitivity in the detection of primary or metastatic hepatic malignancy in the anicteric patient than does the serum alkaline phosphatase The authors believe that the apparent increased sensitivity is related to the greater specificity of this enzyme for hepatobiliary disease

Serum 5'-nucleotidase in patients with tumor in the liver.

The value of serum alkaline phosphatase determination and bromsulphalein test in the diagnosis of metastatic cancer of the liver.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

H Siplet

Author Tools

Chat about Author

Papers

The value of serum alkaline phosphatase determination and bromsulphalein test in the diagnosis of metastatic cancer of the liver.