Synthesis, spectroscopic characterization and biological evaluation studies of Schiff's base derived from naphthofuran-2-carbohydrazide with 8-formyl-7-hydroxy-4-methyl coumarin and its metal complexes.

The main purpose of this paper is to provide an insight into the biological activities of pyrazole derivatives which contain the carbohydrazide moiety.

/pdf/pyrazole-carbohydrazide-derivatives-of-pharmaceutical-3fk66ui6hp.pdf

Pyrazole carbohydrazide derivatives of pharmaceutical interest.

A new series of thiazolyl pyrazoline derivatives linked to benzo[1,3]dioxole moiety: Synthesis and evaluation of antimicrobial and anti-proliferative activities

Synthesis, physico-chemical investigations and biological screening of metal (II) complexes with Schiff base derived from naphthofuran-2-carbohydrazide and citral

Microwave-assisted facile synthesis of [ a ]-annelated pyrazolopyrroloindoles via intramolecular azomethine imine 1,3-dipolar cycloaddition

Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.

https://www.ijpsonline.com/articles/synthesis-and-activity-evaluation-of-21naphtho21-b-furan2ylcarbonyl35disubstituted23dihydro1hpyrazoles.pdf

Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.

---------------------------------------------------------------------------------------------------------------------------------------ABSTRACT Context: - Since there is no any scientific data is available in the management of Alzheimer’s disease by using Sumanas. Hence, the present study is designed to systematically demonstrate the memory enhancing property of Sumanas (SMS) in experimental animal models of Alzheimer’s disease. Objective: - The present study was intended to scientificallyvalidate the effect of Sumanas (SMS), a polyherbal formulation, against scopolamine induced animal model of Alzheimer's disease. Methods: - The memory upgrading action of SMS was established by in vivo (Radial 8 arm maze) process. The Anti- Alzheimer action of Sumanas was evaluated by assessing serum levels of GSH, SOD, total protein, lipid profile and also byhistopathological examination of the brain. the of different parameters in scopolamine

Effect of Polyherbal Formulation on Learning and Memory in Scopolamine Induced Animal Model of Alzheimer’s Disease Neuroprotective effect of Sumanas

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Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.

Effect of Polyherbal Formulation on Learning and Memory in Scopolamine Induced Animal Model of Alzheimer’s Disease Neuroprotective effect of Sumanas