6 Papers
144 Citations
H.R. Lu is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Dofetilide & Long QT syndrome. The author has an hindex of 6, co-authored 6 publications.
Chat about Author
Papers
Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines
H.R. Lu,Eddy Vlaminckx,An N. Hermans,Jutta Rohrbacher,K. Van Ammel,Rob Towart,Michael K. Pugsley,David J. Gallacher +7 more
TL;DR: The regulatory guidelines (ICHS7B) recommending inhibition of the delayed rectifier K+ current (IKr) carried by human ether‐a‐go‐go-related gene (hERG) channels in cardiac cells (the hERG test) as a ‘first line’ test for identifying compounds inducing QT prolongation, have limitations, some of which are outlined here.
136
Detection of proarrhythmia in the female rabbit heart: blinded validation.
TL;DR: Reliable detection of drug‐induced proarrhythmia, especially the potential for polymorphic ventricular tachycardia, is of great importance in the development of new compounds that are safe for the heart and was evaluated in a blinded study.
110
Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations
TL;DR: Rabbit Purkinje fibers can be used as long QT2 and LQT3 (anthopleurin-mimicking) syndrome models, and the relationship between a prolongation of APD(90) or increase in triangulation and the induction of early afterdepolarizations with dofetilide (I(kr) blocker) and anthopleur in (I-Na) modulator is shown.
66
Both β-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of IKs channel blockers in vitro
TL;DR: The study shows that only during beta-adrenoceptor stimulation, pharmacological inhibition of the I(Ks) current plays an important role in the APD recorded from isolated ventricular trabeculae and papillary muscles, but not from Purkinje fibers.
29
QT and JT dispersion in the drug-induced long QT syndrome in anaesthetized rabbits is accurately detected by a three-lead surface ECG measurement.
TL;DR: The present study shows that the measurement of QT and JT dispersion in three surface ECG leads only (aVF, I, V2 or aVf, V1 V4), instead of 12 ECG leading, is an appropriate approach to assess drug-induced heterogeneity or dispersion of ventricular repolarization in anaesthetized rabbits.
10