Implementation and evaluation of an additional GPT-4-based reviewer in PRISMA-based medical systematic literature reviews

The extensive history of pandemics has spanned many centuries, profoundly impacting societies, economies, and public health, and thereby shaping the course of history in various ways. Advances in medicine, science, and public health practices have played a pivotal role in mitigating the effects of pandemics over time. This review explores the scientific landscape of contemporary pandemics, examining their diverse and complex nature. It goes beyond the biological aspects of pandemics to consider socioeconomic, environmental, and technological factors. Through a scientific lens, this study aims to understand the complexities of pandemics and contribute to the expanding knowledge base that helps humanity strengthen its defenses against global health threats. By elucidating the enigmas of pandemics, the study hopes to foster a more resilient and prepared global health environment. Highlighting the importance of a multidisciplinary, cross-disciplinary, and transdisciplinary approach, this exploration emphasizes the critical need to integrate biological, socioeconomic, environmental, and technological domains to develop more robust defenses against these global health challenges. 

Pandemics: past, present, and future: multitasking challenges in need of cross-disciplinary, transdisciplinary, and multidisciplinary collaborative solutions

Exosomal circular RNA (circRNAs) are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids positions them as potential non-invasive biomarkers, revealing the molecular dynamics of cancers. Research in exosomal circRNAs is reshaping our understanding of neoplastic intercellular communication. Exploiting the natural properties of exosomes for targeted drug delivery and disrupting circRNA-mediated pro-tumorigenic signaling can develop new treatment modalities. Therefore, ongoing exploration of exosomal circRNAs in cancer research is poised to revolutionize clinical management of cancer. This emerging field offers hope for significant breakthroughs in cancer care. This review underscores the critical role of exosomal circRNAs in cancer biology and drug resistance, highlighting their potential as non-invasive biomarkers and therapeutic targets that could transform the clinical management of cancer.

Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy

Metode Profile Matching merupakan salah satu dari Sistem Pendukung Keputusan, yaitu suatu system berbasis komputer guna membantu para pengambil keputusan dalam mengatasi permasalahannya untuk mendapatkan atau menghasilkan keputusan yang tepat. [spk] perhitungan dari metode profile matching cukup sederhana, yaitu dengan membandingkan GAP dengan nilai alternative dan kriteria. Ada beberapa hal yang penting yang perlu diketahui mengenai analisis GAP, yaitu table nilai bobot GAP [1]. Selain itu, analisis GAP juga harus memiliki konsep skala prioritas untuk stiap kriteria Karena kemudahan perhitungan dari metode profile matching serta kebutuhan dan tujuan penelitian yang juga sederhana maka peneliti mengambil judul implementasi perhitungan metode profile matching untuk membantu peneliti memberikan jawaban pada komutias akhwat sholeha khususnya kisaran dalam mendapatkan rumah singgah dakwah yang tepat atau cocok untuk dihuni. Adapun tahapan perhitungan dari Profile Matching adalah Penentuan Bobot Nilai GAP, lalu perhitungan dan pengelompokkan core factor dan secoundary factor, selanjutnya perhitungan nilai total tiap kompetensi kriteria dan terakhir perhitungan rangking [2], [3], [4]. Setelah mendapatkan hasil perhitungan yang tepat terhadap rumah singgah dakwah, perhitungan dihentikan dan hasil seleksi diberikan kepada founder KoAS. Hasil dari seleksi rumah singgah dakwah pada Komunitas akhwat Sholehah (KoAS) Kisaran berupa nama dan nilai.

Perhitungan Metode Profile Matching Dalam Seleksi Rumah Singgah Pada Komunitas Akhwat Sholehah (Koas)

During the COVID-19 pandemic, countries adopted mitigation strategies to reduce disruptions to cancer services. We reviewed their implementation across health system functions and their impact on cancer diagnosis and care during the pandemic. A systematic search was performed using terms related to cancer and COVID-19. Included studies reported on individuals with cancer or cancer care services, focusing on strategies/programs aimed to reduce delays and disruptions. Extracted data were grouped into four functions (governance, financing, service delivery, and resource generation) and sub-functions of the health system performance assessment framework. We included 30 studies from 16 countries involving 192,233 patients with cancer. Multiple mitigation approaches were implemented, predominantly affecting sub-functions of service delivery to control COVID-19 infection via the suspension of non-urgent cancer care, modified treatment guidelines, and increased telemedicine use in routine cancer care delivery. Resource generation was mainly ensured through adequate workforce supply. However, less emphasis on monitoring or assessing the effectiveness and financing of these strategies was observed. Seventeen studies suggested improved service uptake after mitigation implementation, yet the resulting impact on cancer diagnosis and care has not been established. This review emphasizes the importance of developing effective mitigation strategies across all health system (sub)functions to minimize cancer care service disruptions during crises. Deficiencies were observed in health service delivery (to ensure equity), governance (to monitor and evaluate the implementation of mitigation strategies), and financing. In the wake of future emergencies, implementation research studies that include pre-prepared protocols will be essential to assess mitigation impact across cancer care services. 

Global review of COVID-19 mitigation strategies and their impact on cancer service disruptions

312P ClinMatch: A clinical trial matching platform that improves trial accessibility among NSCLC patients through comprehensive genomic and clinical profiling

http://www.clinicaloncologyonline.net/article/S0936655523000067/pdf

Global Health System Resilience during Encounters with Stressors – Lessons Learnt from Cancer Services during the COVID-19 Pandemic

The MD Anderson Precision Oncology Decision Support (PODS) group provides genomic support to clinicians to guide enrollment onto genotype-matched trials through gene annotation and reporting on therapeutic actionability of genomic alterations based on NGS reports. PODS was evaluated in a pilot study (Glo-PODS) at a CUHK-affiliated hospital in Hong Kong. Patients with predominantly GI solid tumors who participated in two prospective precision oncology studies (PROCURE, STARTRK) at the CUHK were enrolled. Eligible patients had commercially available NGS panel analysis of their respective tumors. Genomic alterations of their NGS reports were annotated by the PODS to determine therapeutic actionability based on the variant’s known or potential functional and/or therapeutic significance. Data collected: demographics, treatment outcomes and impact on clinical decision and trial enrollment. A total of 144 Chinese patients were enrolled from Feb 2020-2023 - primary diagnosis of colorectal 79.2%, gastric/gastroesophageal 4.9%, pancreatic 4.2%, lung 2.1%, endometrial 0.7%, cervical 0.7% & unknown primary 0.7%. NGS reports were derived from 3 different NGS panels. Of the 131 patients data analyzed to date, 1,367 annotations were performed on 902 unique genomic alterations plus TMB and MSI status. Of the 1367 annotations, 395 (28.9%) were actionable, 317 (23.2%) were potentially actionable, 478 (35%) had unknown actionability, 177 (12.9%) were not actionable. PODS reports matched 41/144 (28.5%) patients to clinical trials at CUHK. Most common reason for low matching trial enrollment was lack of availability of suitable trials. Based on molecular tumor board decisions, PODS report contributed to clinical decisions in 15 patients. Over 50% of genomic alteration annotations were deemed actionable/ potentially actionable by PODS in this cohort of Asian patients with predominantly GI cancers. PODS influenced clinical management in ∼10% of patients, but not trial enrollment. Compared with US experience, our results should be interpreted in the context of differences in cancer-type & clinical trial landscape. 

424P MD Anderson Cancer Center global precision oncology decision support (Glo-PODS) clinical trial genomic support: Pilot program at the Prince of Wales Hospital (Chinese University of Hong Kong - CUHK)

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312P ClinMatch: A clinical trial matching platform that improves trial accessibility among NSCLC patients through comprehensive genomic and clinical profiling

Global Health System Resilience during Encounters with Stressors – Lessons Learnt from Cancer Services during the COVID-19 Pandemic

424P MD Anderson Cancer Center global precision oncology decision support (Glo-PODS) clinical trial genomic support: Pilot program at the Prince of Wales Hospital (Chinese University of Hong Kong - CUHK)