H Chisaka
University of Toronto
3 Papers
H Chisaka is an academic researcher from University of Toronto. The author has contributed to research in topics: Trophoblast & Cytokine. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of H Chisaka include Tohoku University.
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Papers
Prediction of preterm birth in symptomatic women using decision tree modeling for biomarkers.
Jacquelyn L. Hill,M. Karen Campbell,Guang Yong Zou,John R. G. Challis,Gregor Reid,H Chisaka,H Chisaka,Alan D. Bocking +7 more
TL;DR: Results indicate that maternal WBC greater than 12,000/mL prior to 28 weeks' gestation and CRH beyond 28 weeks are the most accurate biomarkers in predicting preterm birth within 48 hours.
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Effect of Pro-inflammatory Cytokines on Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 2 in Cultured Human Term Placental Trophoblast and Human Choriocarcinoma JEG-3 Cells:
TL;DR: It is suggested that TNF-α and IL-1β may increase the amount of cortisol crossing to the placenta and fetal circulation by attenuating 11β-HSD2 activity, potentially contributing to preterm labor and altered fetal outcome in uterine infection.
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IL-1β Treatment Does not Co-ordinately Up-regulate mPGES-1 and COX-2 mRNA Expression, but Results in Higher Degree of Cellular and Intracellular Co-localization of their Immunoreactive Proteins in Human Placenta Trophoblast Cells
TL;DR: It is concluded that mPGES-1 is not involved in the inducible COX-2 mediated pathway for PGE2 biosynthesis at the transcriptional level, however, the treatment with IL-1beta results in a higher degree of co-ordination of the mPGes-1 and COx-2 protein immunolocalization, eliciting P GE2 synthesis.
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