Skin Allergy Versus Ocular Allergy

6 ACKNOWLEDGEMENT 8 LIST OF FIGURES 9 LIST OF TABLES 10 ABBREVIATIONS AND SYMBOLS 11 CHAPTER 1: INTRODUCTION 16 1.1 Age-related macular degeneration 16 1.1.1 Definition of age-related macular degeneration 16 1.1.2 Diagnosis of age-related macular degeneration 17 1.1.3 The patho-physiology of AMD 20 1.2 Atherosclerosis 21 1.2.1 Definition 21 1.2.2 Pathogenesis 21 1.3 The link between atherosclerosis and AMD 22 1.3.1 Hypotheses 22 1.3.2 Epidemiological evidence of co-morbidity of Atherosclerosis and AMD 23 1.4 Aims and Objectives of this project 32 CHAPTER 2: EXTRACELLULAR MATRIX 35 2.1 Bruch’s Membrane and the Vascular Intima: Is There a Common Basis for Age-related Changes and Disease? 35 2.1.1 Structural Comparison of the Bruch’s Membrane and the Vascular Wall 35 2.1.2 Macroscopic Changes of the BM and the Vascular Wall 36 2.1.3 Cell biology of the BM and the vascular wall 37 2.1.4 Lipid accumulation 39 2.1.5 Matrix dysregulation 40 2.1.6 Matrix metalloproteinases 43 2.1.7 Conclusion from Literature Review 44 2.2 Serum Elastin Derived Peptides in Age-related Macular Degeneration 45 2.2.

Investigations of a possible link between age-related macular degeneration and atherosclerosis.

Association of HLA polymorphisms in Age–related macular degeneration

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Association of HLA polymorphisms in Age–related macular degeneration