The oxidation of the carbon-silicon bond

A general approach to the synthesis of a new class of LTD4 antagonists is presented. The key diarylpropane framework was prepared by Claisen−Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.

Practical Route to a New Class of LTD4 Receptor Antagonists

/pdf/ligand-coupling-reactions-of-hypervalent-species-2myra40chm.pdf

Ligand-coupling reactions of hypervalent species

Group 10 transition-metal complexes with metal-silicon bonds derived from 1,2-disilylbenzenes and bis(2-silylphenyl)silane

Isolation of Dinuclear (μ-Silylene)(silyl)nickel Complexes and Si−Si Bond Formation on a Dinuclear Nickel Framework

Ortho lithiation directed by amino groups on silicon in phenylsilane derivatives

Copper-Assisted Displacement Reaction of Nonactivated Iodoarenes with Arenesulfinates. Convenient Alternative Synthesis of Unsymmetrical Diaryl Sulfones.

Silafunctional Compounds in Organic Synthesis. Part 48. Ortho‐ Lithiation Directed by Amino Groups on Silicon in Phenylsilane Derivatives.

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Ortho lithiation directed by amino groups on silicon in phenylsilane derivatives

Copper-Assisted Displacement Reaction of Nonactivated Iodoarenes with Arenesulfinates. Convenient Alternative Synthesis of Unsymmetrical Diaryl Sulfones.

Silafunctional Compounds in Organic Synthesis. Part 48. Ortho‐ Lithiation Directed by Amino Groups on Silicon in Phenylsilane Derivatives.