Gysell M. Mortimer
University of Queensland
11 Papers
51 Citations
Gysell M. Mortimer is an academic researcher from University of Queensland. The author has contributed to research in topics: Protein Corona & Blood proteins. The author has an hindex of 8, co-authored 11 publications.
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Papers
Differential plasma protein binding to metal oxide nanoparticles.
Zhou J. Deng,Gysell M. Mortimer,Tara L. Schiller,Anthony W. Musumeci,Darren J. Martin,Rodney F. Minchin +5 more
TL;DR: The binding of human plasma proteins to commercially available titanium dioxide, silicon dioxide and zinc oxide nanoparticles was investigated and it was found that, despite these particles having similar surface charges in buffer, they bound different plasma proteins.
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Cryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials
Gysell M. Mortimer,Neville J. Butcher,Anthony W. Musumeci,Zhou J. Deng,Darren J. Martin,Rodney F. Minchin +5 more
TL;DR: It is shown that plasma proteins form a hard corona around synthetic layered silicate nanoparticles (LSN) and that one of the principle proteins is serum albumin, and that an additional function for albumin in vivo is demonstrated.
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Drug delivery: Unravelling the stealth effect
TL;DR: Poly(ethylene glycol) helps nanomaterials evade the immune system by modifying the composition of proteins that are adsorbed on the surface of the materials.
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Fluorescent layered double hydroxide nanoparticles for biological studies
Anthony W. Musumeci,Gysell M. Mortimer,Margaret K. Butler,Zhi Ping Xu,Rodney F. Minchin,Darren J. Martin +5 more
TL;DR: The synthesis and fractionation of LDH nanomaterials of well defined spatial characteristics are reported through the careful control of synthesis conditions and the use of ultracentrifugation to achieve purification without causing nanoparticle agglomeration.
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Interaction of human arylamine N-acetyltransferase 1 with different nanomaterials
Zhou J. Deng,Neville J. Butcher,Gysell M. Mortimer,Zhongfan Jia,Michael J. Monteiro,Darren J. Martin,Rodney F. Minchin +6 more
TL;DR: The effects that several different classes of nanoparticles exert on the enzymatic activity of the cytosolic protein human arylamine N-acetyltransferase 1 (NAT1), a drug-metabolizing enzyme widely distributed in the body that is also responsible for the activation and detoxification of known carcinogens, are described.
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