Guy Uechi

TL;DR: A novel mechanism by which ERK1/2 regulates mitochondrial function through direct phosphorylation of TFAM is disclosed, which is downregulated by extracellular signal-regulated protein kinases in cells treated chronically with the complex I inhibitor 1-methyl-4-phenylpyridinium.

TL;DR: The present data show that BM proteins and their domains are asymmetrically organized providing human BMs with side-specific properties, and it is proposed that the bi-functional organization of BMs is an inherent property of B Ms and helps build the basic tissue architecture of metazoans with alternating epithelial and connective tissue layers.

TL;DR: Three types of BMs from adult human eyes, the inner limiting membrane (ILM), the retinal vascular BMs, and the lens capsule, were isolated for analysis and showed that BMs are composed of multiple laminins, collagen IVs, nidogens, and proteoglycans.

TL;DR: Stathmin overexpression protected the cells from taxol-induced abnormal mitoses, and thus induced taxol resistance, and in the stably stathmin-overexpressing clones, compensatory gene expression occurred that resulted in normal rates of cell proliferation and prevented the increase in catastrophe frequency expected in response to Stathmin.