Guy Eelen
Katholieke Universiteit Leuven
101 Papers
424 Citations
Guy Eelen is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Biology & Angiogenesis. The author has an hindex of 39, co-authored 82 publications. Previous affiliations of Guy Eelen include Catholic University of Leuven & Sun Yat-sen University.
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Papers
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock,Maria Georgiadou,Sandra Schoors,Anna Kuchnio,Brian W. Wong,Anna Rita Cantelmo,Annelies Quaegebeur,Bart Ghesquière,Sandra Cauwenberghs,Guy Eelen,Li-Kun Phng,Inge Betz,Bieke Tembuyser,Katleen Brepoels,Jonathan Welti,Ilse Geudens,Inmaculada Segura,Bert Cruys,Franscesco Bifari,Ilaria Decimo,Raquel Blanco,Sabine Wyns,Jeroen Vangindertael,Susana Rocha,Russel T Collins,Sebastian Munck,Dirk Daelemans,Hiromi Imamura,Roland Devlieger,Mark H. Rider,Paul P. Van Veldhoven,Frans Schuit,Ramon Bartrons,Johan Hofkens,Peter Fraisl,Sucheta Telang,Ralph J. DeBerardinis,Luc Schoonjans,Stefan Vinckier,Jason Chesney,Holger Gerhardt,Holger Gerhardt,Mieke Dewerchin,Peter Carmeliet +43 more
TL;DR: It is shown that ECs relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the gly colytic activator PFKFB3 in ECs impaired vessel formation.
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Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Joanna Kalucka,Laura P.M.H. de Rooij,Jermaine Goveia,Katerina Rohlenova,Sébastien J. Dumas,Elda Meta,Nadine V. Conchinha,Federico Taverna,Laure-Anne Teuwen,Koen Veys,Melissa García-Caballero,Shawez Khan,Vincent Geldhof,Liliana Sokol,Rongyuan Chen,Lucas Treps,Mila Borri,Pauline de Zeeuw,Charlotte Dubois,Tobias K. Karakach,Kim D. Falkenberg,Magdalena Parys,Xiangke Yin,Stefan Vinckier,Yuxiang Du,Robert A. Fenton,Luc Schoonjans,Luc Schoonjans,Mieke Dewerchin,Guy Eelen,Bernard Thienpont,Lin Lin,Lars Bolund,Xuri Li,Yonglun Luo,Peter Carmeliet,Peter Carmeliet +36 more
TL;DR: An atlas of >32,000 single-EC transcriptomes from 11 mouse tissues was constructed and 78 EC subclusters were identified, including Aqp7+ intestinal capillaries and angiogenic ECs in healthy tissues and provides a powerful discovery tool and resource value.
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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
Anna Rita Cantelmo,Lena Christin Conradi,Aleksandra Brajic,Jermaine Goveia,Joanna Kalucka,Andreas Pircher,Pallavi Chaturvedi,Johanna Hol,Bernard Thienpont,Laure Anne Teuwen,Sandra Schoors,Bram Boeckx,Joris Vriens,Anna Kuchnio,Koen Veys,Bert Cruys,Lise Finotto,Lucas Treps,Tor Espen Stav-Noraas,Francesco Bifari,Peter C. Stapor,Ilaria Decimo,Kim R. Kampen,Katrien De Bock,Guttorm Haraldsen,Luc Schoonjans,Ton J. Rabelink,Guy Eelen,Bart Ghesquière,Jalees Rehman,Diether Lambrechts,Asrar B. Malik,Mieke Dewerchin,Peter Carmeliet +33 more
TL;DR: It is shown that tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleotide synthesis, which reduces cancer cell invasion, intravasation, and metastasis by normalizing tumor vessels by PFKFB3-blockade treatment, which improved vessel maturation and perfusion.
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Endothelial cell metabolism in normal and diseased vasculature
TL;DR: How EC metabolism differs between the normal and dysfunctional/diseased vasculature and how it relates to or affects the metabolism of other cell types contributing to the pathology is reviewed.
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Sandra Schoors,Ulrike Bruning,Rindert Missiaen,Karla C. S. Queiroz,Gitte Borgers,Ilaria Elia,Annalisa Zecchin,Anna Rita Cantelmo,Stefan Christen,Jermaine Goveia,Ward Heggermont,Lucica Godde,Stefan Vinckier,Paul P. Van Veldhoven,Guy Eelen,Luc Schoonjans,Holger Gerhardt,Mieke Dewerchin,Myriam Baes,Katrien De Bock,Bart Ghesquière,Sophia Y. Lunt,Sarah-Maria Fendt,Peter Carmeliet +23 more
TL;DR: It is reported that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells.