Guy Charron
Université de Montréal
5 Papers
40 Citations
Guy Charron is an academic researcher from Université de Montréal. The author has contributed to research in topics: Mitochondrion & Lanczos resampling. The author has an hindex of 4, co-authored 5 publications.
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Papers
Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development.
TL;DR: This is the first study to demonstrate that mitochondrial NADP+-isocitrate dehydrogenase is a target for inactivation by 4-hydroxynonenal binding, and the pathophysiological significance of the finding is supported by in vivo evidence.
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Decreased cardiac mitochondrial NADP+-isocitrate dehydrogenase activity and expression: a marker of oxidative stress in hypertrophy development.
Mohamed Benderdour,Guy Charron,Blandine Comte,Riwa Ayoub,Diane Beaudry,Sylvain Foisy,Denis deBlois,Christine Des Rosiers +7 more
TL;DR: Low cardiac mNADP+-ICDH activity appears to be a relevant early and persistent marker of mitochondrial oxidative stress-related alterations in hypertrophy development and could also contribute to the aetiology of cardiomyopathy.
63
Alterations in carbohydrate metabolism and its regulation in PPARα null mouse hearts
Roselle Gélinas,François Labarthe,Bertrand Bouchard,Janie Mc Duff,Guy Charron,Martin E. Young,Christine Des Rosiers +6 more
TL;DR: The present study investigated potential alterations in the myocardial utilization of CHOs for energy production and anaplerosis in 12-wk-old peroxisome proliferator-activating receptor-alpha (PPARalpha) null mice to suggest potential mechanisms involved in this defective CHO metabolism.
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A Fourier-Lanczos method for calculating energy levels without storing or calculating matrices
Guy Charron,Tucker Carrington +1 more
TL;DR: In this article, a variational method for calculating vibrational energy levels of polyatomic molecules is developed and applied, which can be used to calculate many energy levels with many vibrational degrees of freedom.
13
Turn down the noise--a blinded evaluation of iterative image reconstruction in radiation therapy computed tomography simulation.
TL;DR: This report is the first to clinically evaluate IR in radiation therapy planning and found that although highly processed images polarized observers, the use of moderate IR was appreciated for most disease sites.
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