Guosheng Han
Second Military Medical University
21 Papers
16 Citations
Guosheng Han is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Glioma & Internal medicine. The author has an hindex of 11, co-authored 19 publications.
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Papers
Long Noncoding RNA miR210HG as a Potential Biomarker for the Diagnosis of Glioma
Weijie Min,Dongwei Dai,Jiaqi Wang,Dandan Zhang,Yuhui Zhang,Guosheng Han,Lei Zhang,Chao Chen,Xiulong Li,Yanan Li,Zhijian Yue +10 more
TL;DR: Findings indicate that miR210HG could be an important biomarker for the diagnosis of glioma, and, as such, large-scale investigations are urgently needed to pave the way from basic research to clinical use.
High expression of leptin receptor leads to temozolomide resistance with exhibiting stem/progenitor cell features in gliobalastoma.
Guosheng Han,Lai-xing Wang,Wen-Yuan Zhao,Yue Zhijian,Zhao Rui,Li Yanan,Xiaoping Zhou,xiaohu hu,Liu Jianmin +8 more
TL;DR: In this study, it is found that leptin receptor-positive glioblastoma cells were resistant to temozolomide (TMZ), and TMZ-resistant cells exhibited high expression of ObR, which explained the reason for TMZ resistance of obR+ cells.
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Overexpression of leptin receptor in human glioblastoma: Correlation with vasculogenic mimicry and poor prognosis.
TL;DR: Wang et al. as discussed by the authors found that lesion recognition by CD31/PAS+ immunohistochemical staining in glioblastoma tissues showed a positive correlation with leptin expression (r = 0.58, P < 0.01).
Osteogenic differentiation of bone marrow mesenchymal stem cells by adenovirus-mediated expression of leptin.
Guosheng Han,Jing Yingying,Yuhui Zhang,Zhi-Jian Yue,Xiaowu Hu,Lai-Xing Wang,Jinchuan Liang,Jianmin Liu +7 more
TL;DR: The findings suggest that genetic engineering of MSCs to express leptin gene may have potential application in the treatment of several genetic diseases and bone reconstruction.
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Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression.
Guosheng Han,Wen-Yuan Zhao,Laixing Wang,Yue Zhijian,Rui Zhao,Li Yanan,Xiaoping Zhou,Xiaowu Hu,Jianmin Liu +8 more
TL;DR: The results indicated that leptin served as a key intermediary linking the accumulation of excess adipokine to the invasion of glioma stem-like cells, which may be a novel therapeutic target for suppressing tumor invasion and recurrence.
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