Guoping Fu
Gulf Coast Regional Blood Center
30 Papers
116 Citations
Guoping Fu is an academic researcher from Gulf Coast Regional Blood Center. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 12, co-authored 20 publications.
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Papers
Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
Guoping Fu,Yuhong Chen,Mei Yu,Mei Yu,Andy Podd,Andy Podd,James Schuman,James Schuman,Yinghong He,Yinghong He,Lie Di,Maryam Yassai,Dipica Haribhai,Paula E. North,Jack Gorski,Jack Gorski,Calvin B. Williams,Demin Wang,Demin Wang,Renren Wen +19 more
TL;DR: It is demonstrated that PLCγ1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-κB.
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.
Mei Yu,Yuhong Chen,Hu Zeng,Yongwei Zheng,Guoping Fu,Wen Zhu,Ulrich Broeckel,Praful Aggarwal,Amy Turner,Geoffrey Neale,Cliff Guy,Nan Zhu,Hongbo Chi,Renren Wen,Demin Wang,Demin Wang,Demin Wang +16 more
TL;DR: PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.
An important role of phospholipase Cγ1 in pre-B-cell development and allelic exclusion
Renren Wen,Yuhong Chen,Yuhong Chen,James Schuman,Guoping Fu,Shoua Yang,Weiguo Zhang,Debra K. Newman,Debra K. Newman,Demin Wang,Demin Wang,Demin Wang +11 more
TL;DR: It is shown that PLCγ1 is expressed throughout B‐cell development, with high expression in B‐ cell progenitors, and is involved in pre‐B‐cell receptor (pre‐BCR) signaling.
Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated NF-κB Activation
TL;DR: It is demonstrated that phosphorylation of Bcl10 at S138 down-regulates B cl10 protein levels and thus negatively regulates T-cell receptor-mediated NF-κB activation.
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Essential Role of Phospholipase Cγ2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis
Renren Wen,Yuhong Chen,Li Bai,Li Bai,Guoping Fu,James Schuman,Xuezhi Dai,Xuezhi Dai,Hu Zeng,Hu Zeng,Chunying Yang,Robert P. Stephan,John L. Cleveland,Demin Wang,Demin Wang +14 more
TL;DR: PLCγ2 plays an important role in pre-BCR-mediated early B-cell development, and its deficiency leads to markedly increased pools of the most at-risk large pre-B cells, which display hyperresponsiveness to IL-7 and express high levels of RAGs, making them prone to secondary mutations and Myc-induced malignancy.
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