The invention discloses a preparation method for an enkephalinase inhibitor intermediate. According to the preparation method, a target compound with a formula I as described in the specification is prepared by using a compound as shown in a formula IV which is described in the specification as an initial material through a reaction with few steps, wherein the compound with the formula I can be used for preparation of an enkephalinase inhibitor drug namely Sacubtril. In the formula I and the formula IV, R is selected from the group consisting of H, methyl, ethyl or other lower alkyl.

Preparation method for enkephalinase inhibitor intermediate

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

New process for early sacubitril intermediates

Preparation method of sacubitril valsartan sodium impurity

The invention discloses a preparation method of an intermediate compound (R)-tert-butyl (1-((1,1'-diphenyl)-4-yl)-3-hydroxypropane-2-yl) carbamate. The preparation method is represented as the formulashown in the description. According to the preparation method, the steps are simple and short, the reaction yield is increased, reaction conditions are mild, most of the intermediates obtained in thereaction process are not required to be purified and can be subjected to the next reaction directly, large-batch synthesis is facilitated, chiral amine with stereospecificity is efficiently synthesized with aminotransferase, and the preparation method is more suitable for industrial production.

Preparation method of Sacubitril intermediate

The present invention relates to a sacubitril intermediate and a preparation method thereof, the sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound; In addition, the intermediate can be used as a raw material to synthesize sacubitril The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost and environment friendly, and so on, which is very suitable for industrial production

Sacubitril intermediate and preparation method thereof

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Sacubitril intermediate and preparation method thereof