63 Papers
402 Citations
Guo Jun Liu is an academic researcher from Australian Nuclear Science and Technology Organisation. The author has contributed to research in topics: Translocator protein & Glutamate receptor. The author has an hindex of 21, co-authored 60 publications. Previous affiliations of Guo Jun Liu include Australian Synchrotron & University of Western Australia.
Chat about Author
Papers
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
Richard B. Banati,Ryan J. Middleton,Ronald Chan,Claire R. Hatty,Winnie Wai-Ying Kam,Candice Quin,Manuel B. Graeber,Arvind Parmar,David Zahra,Paul D. Callaghan,Sandra Fok,Nicholas R. Howell,Marie Gregoire,Alexander M Szabo,Tien Pham,Emma Davis,Guo Jun Liu,Guo Jun Liu +17 more
TL;DR: It is shown that global C57BL/6-Tspotm1GuWu(GuwiyangWurra)-knockout mice are viable with normal growth, lifespan, cholesterol transport, blood pregnenolone concentration, protoporphyrin IX metabolism, fertility and behaviour, and while the activation of microglia after neuronal injury appears to be unimpaired, microglial output is significantly less ATP, suggesting reduced metabolic activity.
The 18 kDa translocator protein, microglia and neuroinflammation.
Guo Jun Liu,Ryan J. Middleton,Claire R. Hatty,Winnie Wai-Ying Kam,Winnie Wai-Ying Kam,Ronald Chan,Tien Pham,Meredith Harrison-Brown,Meredith Harrison-Brown,Eoin Dodson,Kelly Veale,Richard B. Banati +11 more
TL;DR: Against prediction, full Tspo knockout mice are viable and across their lifespan do not show the phenotype expected if cholesterol transport and steroid synthesis were significantly impaired, so the “translocation” function of TSPO remains to be better substantiated.
213
Selective, high-contrast detection of syngeneic glioblastoma in vivo.
Richard B. Banati,Paul Wilcox,Ran Xu,Grace Yin,Emily Si,Eric Taeyoung Son,Mauricio Shimizu,R. M. Damian Holsinger,Arvind Parmar,David Zahra,Andrew Arthur,Ryan J. Middleton,Guo Jun Liu,Arnaud Charil,Manuel B. Graeber +14 more
TL;DR: An animal model that allows high-contrast imaging of wild-type glioma cells by positron emission tomography using [18 F]PBR111 using the mitochondrial 18 kDa Translocator Protein (TSPO) combined with the exclusive expression of TSPO makes it possible, for the first time, to unequivocally and with uniquely high biological contrast identify peri-tumoral gliomas cell invasion at preclinical stages in vivo.
The impact of high and low dose ionising radiation on the central nervous system
Calina Betlazar,Ryan J. Middleton,Richard B. Banati,Richard B. Banati,Guo Jun Liu,Guo Jun Liu +5 more
TL;DR: TSPO is discussed as a potential biomarker of radiation-induced effects of pathology in the brain based on the known responsiveness of TSPO expression to a wide range of noxious stimuli.
159
Sifting through the surfeit of neuroinflammation tracers.
Paul Cumming,Bjorn Burgher,Omkar L. Patkar,Omkar L. Patkar,Michael Breakspear,Neil Vasdev,Paul Thomas,Guo Jun Liu,Richard B. Banati,Richard B. Banati +9 more
TL;DR: The first phase of molecular brain imaging of microglial activation in neuroinflammatory conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the prototype isoquinoline li...
110