Gunter P. Eckert
Goethe University Frankfurt
131 Papers
1.2K Citations
Gunter P. Eckert is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Cholesterol & Biology. The author has an hindex of 49, co-authored 120 publications. Previous affiliations of Gunter P. Eckert include University of Giessen.
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Papers
Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects
TL;DR: Findings in AD animal and cell models indicate that mitochondrial protection and subsequent reduction of oxidative stress are important targets for prevention and long-term treatment of early stages of AD.
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Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex.
Leslie N. Johnson-Anuna,Gunter P. Eckert,Jan H. Keller,Urule Igbavboa,Cornelia Franke,Thomas Fechner,Manfred Schubert-Zsilavecz,Michael Karas,Walter E. Müller,W. Gibson Wood +9 more
TL;DR: To understand the molecular targets of statins in brain, DNA microarrays were used to identify gene expression patterns in the cerebral cortex of mice chronically treated with lovASTatin, pravastatin, and simvastatin and revealed 15 genes involved in cell growth and signaling and trafficking that were similarly changed by all three statins.
213
Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.
TL;DR: The purpose of this review was to examine the above‐mentioned issues, discuss the pros and cons of the cholesterol‐AD hypothesis, involvement of other lipids in the mevalonate pathway, and consider that AD may impact cholesterol homeostasis.
194
Statin effects on cholesterol micro-domains in brain plasma membranes.
TL;DR: In conclusion, this data give some first insight in the mode of action of statins to reduce the prevalence of AD in clinical trials.
178
Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo.
Sebastian Schaffer,Maciej Podstawa,Francesco Visioli,Paola Bogani,Walter E. Müller,Gunter P. Eckert +5 more
TL;DR: Ex vivo data provide the first evidence of neuroprotective effects of oral hydroxytyrosol intake, as shown by reduced basal and stress-induced lipid peroxidation and an effect suggestive of cytoprotection.
172