Gunnar Hapke
Roswell Park Cancer Institute
12 Papers
77 Citations
Gunnar Hapke is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 7 publications.
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Papers
Induction of Biphasic DNA Double Strand Breaks and Activation of Multiple Repair Protein Complexes by DNA Topoisomerase I Drug 7-Ethyl-10-hydroxy-camptothecin
TL;DR: SN-38, an active metabolite of irinotecan, was chosen to characterize DNA double strand breaks and repair mechanisms induced by this type of drugs using a human head and neck squamous cell carcinoma cell line A253 and showed that 2-h exposure of cells to an IC(50) concentration of SN-38 induces biphasic DNA double-strand break (DSBs).
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Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1alpha expression, resulting in reduced angiogenesis.
Ming-Biao Yin,Li Zr,Karoly Toth,Shousong Cao,Farukh A. Durrani,Gunnar Hapke,Arup Bhattacharya,Rami G. Azrak,Cheryl Frank,Y. M. Rustum +9 more
TL;DR: Therapeutic synergy between MSC and irinotecan was demonstrated in mice bearing human squamous cell carcinoma of the head and neck tumors and results suggest that observed therapeutic synergy correlates with the inhibition of neoangiogenesis through the downregulation of COX-2, iNOS and HIF-1α expression.
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Chk1 signaling pathways that mediated G2M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350
Ming-Biao Yin,Gunnar Hapke,Jiaxi Wu,Rami G. Azrak,Cheryl Frank,Carol Wrzosek,Youcef M. Rustum +6 more
TL;DR: The data indicate that the chk1 signaling pathways that mediate cell cycle checkpoint are associated with cellular resistance to BNP1350 in the A253/BNPR cell line.
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The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer.
TL;DR: The data have shown that inhibition of the chk1 pathway accompanied by the abrogation of G2 arrest is involved in sensitizing A253 cells to BNP1350 by bax gene transfer, suggesting that apoptosis promoting and G2/M DNA damage checkpoint regulatory pathways are promoted.
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Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance.
TL;DR: Chk1 regulation pathways, DNA MMR and p73, as well as altered apoptotic cell death involved in the cell resistance toward DNA damaging agents will be reviewed in this article.
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