The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Dual variable domain immunoglobulins and uses thereof

The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as monomeric polypeptides. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including immunotherapeutic applications.

Binding domain-immunoglobulin fusion proteins

Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.

Single-chain multivalent binding proteins with effector function

Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

IL-17 binding proteins

Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

IL-1 binding proteins

A first bispecific antibody molecule comprises at least one binding site with a variable domain on a light chain (VL) and a variable domain for the T-cell receptor CD-28, linked thereto on a heavy chain (Vh). The antibody molecule further comprises at least one binding site with a variable domain on a heavy chain (VH) and a variable domain for a tumour antigen, linked thereto on a light chain (VL). The variable domains on the heavy chains for both specificities are connected to each other by means of a peptide linker. A second bispecific antibody molecule is bivalent for CD-28 and at least monovalent for the tumour antigen.

Bispecific anti-cd28 antibody molecule

Ein erstes bispezifisches Antikorper-Molekul weist zumindest eine Bindestelle mit einer variablen Domane einer leichten Kette (VL) und eine damit verbundene variable Domane einer schweren Kette (VH) fur den T-Zell-Rezeptor CD28 auf. Das Antikorper-Molekul weist ausserdem zumindest eine Bindestelle mit einer variablen Domane einer schweren Kette (VH) und eine damit verbundene variable Domane einer leichte Kette (VL) fur ein Tumor-Antigen auf. Die variablen Domanen der schweren Ketten der beiden Spezifitaten sind miteinander durch einen Peptidlinker verbunden. Ein zweites bispezifisches Antikorper-Molekul ist bivalent fur CD28 und zumindest monovalent fur das Tumor-Antigen.

Bispezifisches anti-cd28-antikörper-molekül

Ein erstes bispezifisches Antikorper-Molekul weist zumindest eine Bindestelle mit einer variablen Domane einer leichten Kette (V¶L¶) und eine damit verbundene variable Domane einer schweren Kette (V¶H¶) fur den T-Zell-Rezeptor CD28 auf. Das Antikorper-Molekul weist auserdem zumindest eine Bindestelle mit einer variablen Domane einer schweren Kette (V¶H¶) und eine damit verbundene variable Domane einer leichten Kette (V¶L¶) fur ein Tumor-Antigen auf. Die variablen Domanen der schweren Ketten der beiden Spezifitaten sind miteinander durch einen Peptidlinker verbunden. Ein zweites bispezifisches Antikorper-Molekul ist bivalent fur CD28 und zumindest monovalent fur das Tumor-Antigen.

Bispezifisches Antikörper-Molekül

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Bispecific anti-cd28 antibody molecule

Bispezifisches anti-cd28-antikörper-molekül

Bispezifisches Antikörper-Molekül