Acute kidney injury associated with non-steroidal anti-inflammatory drugs.

Edible Plants in Health and Diseases: Volume 1 : Cultural, Practical and Economic Value

The use of a new medication (e.g., potassium supplementation) for managing a drug‐induced adverse event (e.g., loop diuretic‐induced hypokalemia) constitutes a prescribing cascade. However, loop diuretics are often stopped while potassium may be unnecessarily continued (i.e., relic). We aimed to quantify the occurrence of relics using older adults previously experiencing a loop diuretic‐potassium prescribing cascade as an example.

Continued potassium supplementation use following loop diuretic discontinuation in older adults: An evaluation of a prescribing cascade relic

Jatropha tanjorensis Euphorbiaceae Ameliorates Aspirin-Induced Hepatotoxicity and Maintain Electrolytes Balance in Albino Wistar Rats

Hyperkalemia is a known adverse effect of trimethoprim-sulfamethoxazole, usually occurring at high doses. However, fatal hyperkalemia at low doses has rarely been reported. We present the case of an 80-year-old Japanese woman who experienced a cardiac arrest due to severe hyperkalemia after starting low-dose trimethoprim-sulfamethoxazole. This case suggests that trimethoprim-sulfamethoxazole can cause severe hyperkalemia and sudden death, even at low doses. When trimethoprim-sulfamethoxazole is administered, even at low doses, periodic monitoring of electrolyte levels is necessary, with the interval depending on concomitant medications and renal function.

Life-Threatening Hyperkalemia following Low-Dose Trimethoprim-Sulfamethoxazole: A Case Report

Introduction The association between continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) and hyperkalemia is not consistent in the literature and creates grounds for further large-scale trials, particularly in patients with a chronic disease that affects renal function, such as diabetes mellitus (DM). In this study, we will compare mean serum potassium level and the prevalence of hyperkalemia in diabetic and non-diabetic patients based on their use of NSAIDs. Methods This case-control study was conducted in the internal medicine unit of a tertiary care hospital from May 2019 to December 2020. After taking informed consent, 700 patients with a confirmed diagnosis of type 2 DM, of either gender, were enrolled in the study via consecutive convenient non-probability technique. Another set of 700 participants from the public were enrolled as the reference or control group. Continuous NSAID use was defined as NSAID used for a minimum of 20 days in the last 30 days. Blood was drawn via phlebotomy and sent to the laboratory to test for potassium level. Results Serum potassium level was significantly higher in diabetic patients with continuous NSAID use compared to the diabetic patients without continuous use (4.8 ± 0.8 mmol/L vs. 4.5 ± 0.7 mmol/L; p-value: 0.0001). Additionally, serum potassium level was significantly higher in non-diabetic patients with continuous NSAID use compared to non-diabetic patients without continuous use (4.3 ± 0.7 mmol/L vs. 3.9 ± 0.5 mmol/L; p-value: 0.0001)  Conclusion In this study, the patients with continuous use of NSAIDs had higher levels of serum potassium level compared to patients without continuous use of NSAIDs. This difference was even higher in diabetic patients.

Association Between Long-Term Use of Non-steroidal Anti-inflammatory Drugs and Hyperkalemia in Diabetic Patients

Cultural, Practical, and Economic Significance of Some Edible Medicinal Plants from Gilgit-Baltistan Pakistan

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Association Between Long-Term Use of Non-steroidal Anti-inflammatory Drugs and Hyperkalemia in Diabetic Patients

Cultural, Practical, and Economic Significance of Some Edible Medicinal Plants from Gilgit-Baltistan Pakistan